Sodium ferulate modified gene expression profile of oxidized low-density lipoprotein-stimulated human umbilical vein endothelial cells.

Zhang D; Bi Z; Li

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Sodium ferulate modified gene expression profile of oxidized low-density lipoprotein-stimulated human umbilical vein endothelial cells.

机译：阿魏酸钠修饰的氧化型低密度脂蛋白刺激的人脐静脉内皮细胞的基因表达谱。

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Oxidized low-density lipoprotein (ox-LDL) is known to trigger vascular injury in atherosclerosis development. Sodium ferulate is an effective component from Chinese medicines with various beneficial cardiovascular pharmacological activities. Here, we investigated the effects of sodium ferulate on the gene expression profile of ox-LDL-stimulated endothelial cells. Cultured human umbilical vein endothelial cells (HUVECs) were treated with ox-LDL (50 microg/mL) in the absence or presence of sodium ferulate (5 micromol/L). Sodium ferulate significantly reduced ox-LDL-induced endothelial cell death as evaluated by cell viability assay. Human oligonucleotide microarray analysis demonstrated that a total of 32 ox-LDL-induced genes were significantly downregulated to control levels by sodium ferulate. These genes included members from families of chemokine, inflammatory factor, growth factor, and nuclear receptor. These data provided an overview of the gene expression profile of endothelial cells in response to ox-LDL and sodium ferulate, and demonstrated that sodium ferulate could regulate the expression of inflammation-related genes in endothelial cells and has the potential to benefit endothelial function in the setting of atherosclerosis.

机译：氧化的低密度脂蛋白（ox-LDL）已知在动脉粥样硬化发展中触发血管损伤。阿魏酸钠是中药的有效成分，具有多种有益的心血管药理活性。在这里，我们调查了阿魏酸钠对ox-LDL刺激的内皮细胞基因表达谱的影响。在不存在或存在阿魏酸钠（5 micromol / L）的情况下，用ox-LDL（50 microg / mL）处理培养的人脐静脉内皮细胞（HUVEC）。如通过细胞活力测定所评估的，阿魏酸钠显着降低了ox-LDL诱导的内皮细胞死亡。人寡核苷酸微阵列分析表明，阿魏酸钠将总共32个ox-LDL诱导的基因显着下调至控制水平。这些基因包括来自趋化因子，炎症因子，生长因子和核受体家族的成员。这些数据概述了ox-LDL和阿魏酸钠对内皮细胞的基因表达谱的影响，并证明阿魏酸钠可以调节内皮细胞中炎症相关基因的表达，并可能有益于内皮细胞的内皮功能。动脉粥样硬化的设置。

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《Journal of cardiovascular pharmacology and therapeutics》 |2009年第4期|共12页
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Zhang D; Bi Z; Li;
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中图分类药学;
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1. Sodium ferulate modified gene expression profile of oxidized low-density lipoprotein-stimulated human umbilical vein endothelial cells. [J] . Zhang D, Bi Z, Li Journal of cardiovascular pharmacology and therapeutics . 2009,第4期

机译：阿魏酸钠修饰的氧化型低密度脂蛋白刺激的人脐静脉内皮细胞的基因表达谱。
2. Tongxinluo Regulates Expression of Tight Junction Proteins and Alleviates Endothelial Cell Monolayer Hyperpermeability via ERK-1/2 Signaling Pathway in Oxidized Low-Density Lipoprotein-Induced Human Umbilical Vein Endothelial Cells [J] . Chengcheng Chang, Hongli Liu, Cong Wei, Evidence-based complementary and alternative medicine: eCAM . 2017,第3期

机译：Tongxinluo调节紧密结蛋白的表达，并通过ERK-1/2信号传导途径在氧化低密度脂蛋白诱导的人脐静脉内皮细胞中缓解内皮细胞单层高透模性
3. Carbamylated low-density lipoprotein increases reactive oxygen species (ROS) and apoptosis via lectin-like oxidized LDL receptor (LOX-1) mediated pathway in human umbilical vein endothelial cells. [J] . Son JN, Lho Y, Shin S, International Journal of Cardiology . 2011,第3期

机译：氨基甲酸酯化的低密度脂蛋白通过人脐静脉内皮细胞中的凝集素样氧化LDL受体（LOX-1）介导的途径增加了活性氧（ROS）和细胞凋亡。
4. A tag-less method for the direct isolation of HUVEC (human umbilical vein endothelial cells) by gravitational field-flow fractionation as a starting point for gene expression analysis [C] . Lattuada D., Roda B., Pignatari C., NSTI-Nanotech 2010;NSTI nanotechnology conference and expo;Bio Nanotech 2010;NSTI bio nano conference and expo;Microtech 2010;Microtechnology conference and expo;WCM 2010;Workshop on compact modeling;NSTI nanotech ventures;TechConnect summit;Clean technology . 2010

机译：通过重力场流分级分离作为基因表达分析起点的无标签方法直接分离HUVEC（人脐静脉内皮细胞）
5. Effects of cyclic strain on the gene expression of human umbilical vein endothelial cells as determined through microarray technology. [D] . Frye, Stacie Renee. 2003

机译：通过芯片技术确定循环应变对人脐静脉内皮细胞基因表达的影响。
6. Tongxinluo Regulates Expression of Tight Junction Proteins and Alleviates Endothelial Cell Monolayer Hyperpermeability via ERK-1/2 Signaling Pathway in Oxidized Low-Density Lipoprotein-Induced Human Umbilical Vein Endothelial Cells [O] . Chengcheng Chang, Hongli Liu, Cong Wei, 2017

机译：通心络调节紧密连接蛋白的表达并通过氧化的低密度脂蛋白诱导的人脐静脉内皮细胞中的ERK-1 / 2信号通路减轻内皮细胞单层通透性
7. Retraction Note to: “Sodium Ferulate Inhibits High-Fat Diet-Induced Inflammatory Factors Expression in Human Umbilical Vein Endothelial Cells” [O] . Junliang Tao, Dongxian Zhang, Yonghong Man, 2019

机译：撤回注意：“钠发射抑制了人脐静脉内皮细胞中的高脂肪饮食诱导的炎症因子”
8. Modulation of Oxidative Stress by Gamma-Glutamylcysteine (GGC) and Conjugated Linoleic Acid (CLA) Isomer Mixture in Human Umbilical Vein Endothelial Cells. [R] . Nakamura, Y. K., Dubick, M. A., Omaye, S. T. 2012

机译：γ-谷氨酰半胱氨酸（GGC）和共轭亚油酸（CLa）异构体混合物对人脐静脉内皮细胞的氧化应激的调节作用。

Sodium ferulate modified gene expression profile of oxidized low-density lipoprotein-stimulated human umbilical vein endothelial cells.

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