Drug-eluting balloons: where are we and what are the problems?

Beatrix Schnorr; Ulrich Speck1; Bruno Scheller

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Drug-eluting balloons: where are we and what are the problems?

机译：药物洗脱气球：我们在哪里？问题在哪里？

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The starting point of percutaneous transluminal coronary angioplasty was defined by Andreas Griintzig in 1977 [l]. He developed the novel technique of revascularization and established a new speciality - interventional cardiology.Since that time, interventionalists have been confronted with the problems of vessel recoil during the procedure and restenosis within the first 6 months of balloon angioplasty. In spite of progress in some indications, in others these challenges have lost nothing of their significance, motivating investigators to pursue their research efforts with a view to finding new strategies for overcoming these difficulties.

机译：1977年Andreas Griintzig定义了经皮腔内冠状动脉成形术的起点[1]。他开发了新的血运重建技术，并建立了一个新的专业-介入心脏病学。从那时起，介入治疗人员就面临着在球囊血管成形术的前6个月过程中血管回缩和再狭窄的问题。尽管在某些适应症方面取得了进展，但在另一些适应症中，这些挑战却丝毫没有失去意义，这促使研究人员继续进行研究工作，以期找到克服这些困难的新策略。

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《Clinical investigation》 |2011年第6期|共3页
作者
Beatrix Schnorr; Ulrich Speck1; Bruno Scheller;
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中图分类预防医学、卫生学;
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1. A multicenter randomized comparison of drug-eluting balloon plus bare-metal stent versus bare-metal stent versus drug-eluting stent in bifurcation lesions treated with a single-stenting technique: Six-month angiographic and 12-month clinical results of the drug-eluting balloon in bifurcations trial [J] . StellaP.R., BelkacemiA., DuboisC., Catheterization and cardiovascular interventions: Official journal of the Society for Cardiac Angiography & Interventions . 2012,第7期

机译：用单支架技术治疗分叉病变中药物洗脱球囊，裸金属支架，裸金属支架与药物洗脱支架的多中心随机比较：六个月的血管造影和十二个月的药物洗脱临床结果分叉试验中的球囊
2. The efficacy and safety of drug-eluting balloons for the treatment of in-stent restenosis as compared with drug-eluting stents and with conventional balloon angioplasty [J] . The Korean Journal of Internal Medicine . 2016,第3期

机译：与药物洗脱支架和常规气球成形术相比，药物洗脱气球治疗支架再狭窄的疗效和安全性
3. Primary percutaneous coronary intervention by drug-eluting balloon angioplasty: The nonrandomized fourth arm of the DEB-AMI (drug-eluting balloon in ST-segment elevation myocardial infarction) trial [J] . Nijhoff Freek, Agostoni Pierfrancesco, Belkacemi Anouar, Catheterization and cardiovascular interventions: Official journal of the Society for Cardiac Angiography & Interventions . 2015,第Suppla1期

机译：药物洗脱球囊血管成形术的主要经皮冠状动脉介入治疗：DEB-AMI（ST段抬高型心肌梗死中的药物洗脱球囊）的非随机四臂试验
4. Dextran Sulfate Thin Films: A Novel Drug Delivery Platform for Drug-Eluting Balloon Applications [C] . Sujan Lamichhane, Gopinath Mani Society for Biomaterials annual meeting and exposition . 2015

机译：硫酸葡聚糖薄膜：用于药物洗脱球囊应用的新型药物递送平台
5. An Experimental Study of Double-Balloon and Single-Balloon Catheters and the Causal Association with Maintenance of an Air-Tight Rectal Seal and Tissue Damage in White Colony Yorkshire Swine [D] . Simmons, Cephus E., Sr. 2019

机译：双气球和单球囊导管的实验研究及对着气密直肠密封和白色殖民地约克郡猪的组织损伤的因果关系
6. The efficacy and safety of drug-eluting balloons for the treatment of in-stent restenosis as compared with drug-eluting stents and with conventional balloon angioplasty [O] . Pyung Chun Oh, Soon Yong Suh, Woong Chol Kang, 2016

机译：与药物洗脱支架和常规球囊血管成形术相比药物洗脱球囊治疗支架内再狭窄的疗效和安全性
7. First results of the DEB-AMI (drug eluting balloon in acute ST-segment elevation myocardial infarction) trial: a multicentre randomized comparison of drug-eluting balloon plus bare-metal stent versus bare-metal stent versus drug-eluting stent in primary percutaneous coronary intervention with 6-month angiographic, intravascular, functional, and clinical outcomes AnouarBelkacemiPierfrancescoAgostoniHendrik M.NathoeMichielVoskuilChunLaiShaoEricVan BelleThierryWildberghLuigiPolitiPieter A.DoevendansGiuseppe M.SangiorgiPieter R.StellaFirst results of the DEB-AMI (drug eluting balloon in acute ST-segment elevation myocardial infarction) trial: a multicentre randomized comparison of drug-eluting balloon plus bare-metal stent versus bare-metal stent versus drug-eluting stent in primary percutaneous coronary intervention with 6-month angiographic, intravascular, functional, and clinical outcomesJ. Am. Coll. Cardiol.59201223272337 [O] . Khànal Suraj, Bahl Ajay 2012

机译：DEB-AMI（急性ST段抬高型心肌梗死中的药物洗脱球囊）试验的初步结果：在原发性经皮冠状动脉中药物洗脱球囊与裸金属支架，裸金属支架与药物洗脱支架的多中心随机比较6个月血管造影，血管内，功能和临床结局的干预AnouarBelkacemiPierfrancescoAgostoniHendrik M.NathoeMichielVoskuilChunLaiShaoEricVan BelleThierryWildberghLuigiPolitiPieter A.DoevendansGiuseppe M.SangiorgiPieter R.药物洗脱球囊联合裸金属支架，裸金属支架与药物洗脱支架在6个月血管造影，血管内，功能和临床结局的主要经皮冠状动脉介入治疗中的多中心随机比较J.上午。 Coll。卡多醇59201223272337
8. Determination of the Shape of a Free Balloon. Balloons with Superpressure, Subpressure and Circumferential Stress: And Capped Balloons [R] . Smalley, J. H. 1964

机译：确定自由球囊的形状。具有超压，负压和周向应力的气球：以及加盖气球

Drug-eluting balloons: where are we and what are the problems?

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