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首页> 外文期刊>Journal of Crohn’s & colitis >Association of adherence to therapy and complementary and alternative medicine use with demographic factors and disease phenotype in patients with inflammatory bowel disease
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Association of adherence to therapy and complementary and alternative medicine use with demographic factors and disease phenotype in patients with inflammatory bowel disease

机译：炎性肠病患者坚持治疗以及补充和替代药物的使用与人口统计学因素和疾病表型的关系

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Background and aims: Previous studies have suggested an increasing use of complementary and alternative medicine (CAM) in patients with inflammatory bowel disease (IBD). Furthermore, a significant number of IBD patients fail to comply with treatment. The aim of our study was to evaluate the prevalence of non-adherence and the use of CAM in Hungarian patients with IBD. Methods: A total of 655 consecutive IBD patients (CD: 344, age: 38.2 [SD 12.9]years; UC: 311, age: 44.9 [15.3]years) were interviewed during the specialist visit by self-administered questionnaire including demographic and disease-related data as well as items analyzing the extent of non-adherence and CAM use. Patients taking more than 80% of each prescribed medication were classified as adherent.Results: The overall rate of self-reported non-adherence (CD: 20.9%, UC: 20.6%) and CAM (CD: 31.7%, UC: 30.9%) use did not differ between Crohn's disease (CD) and ulcerative colitis (UC). The most common causes of non-adherence were: forgetfulness (47.8%), too many/unnecessary pills (39.7%), being afraid of side effects (27.9%) and too frequent dosing. Most common forms of CAM were herbal tea (47.3%), homeopathy (14.6%), special diet (12.2%), and acupuncture (5.8%). In CD, disease duration, date of last follow-up visit, educational level and previous surgeries were predicting factors for non-adherence. Alternative medicine use was associated in both diseases with younger age, higher educational level, and immunosuppressant use. In addition, CAM use in UC was more common in females and in patients with supportive psychiatric/psychological therapy.Conclusions: Non-adherence and CAM use is common in patients with IBD. Special attention should be paid to explore the identified predictive factors during follow-up visits to improve adherence to therapy and improving patient-doctor relationship.
机译：背景和目的：先前的研究表明，在炎症性肠病（IBD）患者中越来越多地使用补充和替代药物（CAM）。此外，大量的IBD患者未能遵从治疗。我们研究的目的是评估匈牙利IBD患者不依从的患病率和CAM的使用。方法：在专家访视期间，通过自我调查表（包括人口统计学和疾病）对总共655名连续IBD患者（CD：344，年龄：38.2 [SD 12.9]年; UC：311，年龄：44.9 [15.3]年）进行了访谈。相关数据以及分析不遵守和CAM使用程度的项目。每种处方药物的使用率超过80％的患者被列为依从性。结果：自我报告的不依从性总体比率（CD：20.9％，UC：20.6％）和CAM（CD：31.7％，UC：30.9％ ）克罗恩病（CD）和溃疡性结肠炎（UC）的使用无差异。引起不依从的最常见原因是：健忘（47.8％），过多/不必要的药丸（39.7％），害怕副作用（27.9％）和过于频繁的给药。 CAM的最常见形式是凉茶（47.3％），顺势疗法（14.6％），特殊饮食（12.2％）和针灸（5.8％）。在CD中，疾病持续时间，上次随访日期，教育水平和以前的手术是不依从性的预测因素。在年龄较小，文化程度较高和使用免疫抑制剂的两种疾病中，均使用替代药物。此外，UC和UC的CAM使用在女性和接受支持性精神病/心理治疗的患者中更为常见。结论：IBD患者不依从和CAM的使用很普遍。在随访期间应特别注意探索已确定的预测因素，以提高对治疗的依从性并改善医患关系。

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