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首页> 外文期刊>Journal of drug research. >The Protective Effect of Vitamin С and Olive Ой Against the Ordiotoxicity Induced by Cyclophosphamide in Rats
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The Protective Effect of Vitamin С and Olive Ой Against the Ordiotoxicity Induced by Cyclophosphamide in Rats

机译：维生素С和橄榄油Ой对大鼠环磷酰胺所致的口腔毒性的保护作用。

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This study was carried out to evaluate the protective role of Vit. С and olive oil against cyclophosphamide (CPA)-induced cardiotoxicity in rats. Sprague-Dawley rats weighing 220 ±30 g were divided into 6 groups, the 1st gp. served as control, the 2nd and 3rd gps., were treated orally, with 120mg/kg Vit.C or 1 ml/rat olive oil, respectively, the 4th gp. was injected with 150 mg/kg CPA intrapritoneally (i.p.). The 5th and 6th groups were treated with Vit.C or olive oil after CPA, respectively. All treatments were done daily for 4 weeks. 24 hours after treatment, the animals were weighed, the blood was collected for biochemical analysis, then the animals were sacrificed and the heart was removed for reactive oxygen species (ROS), antioxidant detection, and histopathological examination. The obtained result showed that the treatment with CPA significantly increased (P<0.05) cholesterol, triglyceride (TG), LDH levels as well as relative weight ratio of heart and body weight when compared to control group. Administration of Vit.C or olive oil, significantly decreased (P<0.05) the levels of cholesterol, TG and LDH as well as heart body weight ratio. ROS parameters showed a significant increase (P<0.05) in malondealhyde (MDA), and significant decrease (PO.05) in glutathione (GSH) and superoxide dismutase (SOD) following CPA administration when compared with control. Administration of Vit.C or olive oil after CPA injection significantly decreased (P<0.05) the level of MDA and significantly increased (P<0.05) the levels of both GSH and SOD when compared with CPA group. The present data revealed that Vit.C and olive oil administration improved the heart histopathological changes in rats injected with CPA. These findings demonstrated that Vit.C and olive oil can be used as a potent free radical scavenger in animals to minimize the toxic effects of treatment with anticancer drugs.
机译：进行该研究以评价Vit的保护作用。 С和橄榄油抗环磷酰胺（CPA）诱导的大鼠心脏毒性。将体重为220±30 g的Sprague-Dawley大鼠分为6组，第一组。作为对照，分别以120mg / kg的Vit.C或1 ml /大鼠的橄榄油口服治疗第2和第3 gps。第4 gp。经腹膜内（i.p.）注射150mg / kg CPA。 CPA后，分别用Vit.C或橄榄油治疗第5和第6组。每天进行所有治疗，持续4周。治疗后24小时，称重动物，收集血液进行生化分析，然后处死动物并取出心脏进行活性氧（ROS），抗氧化剂检测和组织病理学检查。获得的结果表明，与对照组相比，CPA治疗显着提高（P <0.05）胆固醇，甘油三酸酯（TG），LDH水平以及心脏和体重的相对重量比。 Vit.C或橄榄油的使用显着降低（P <0.05）胆固醇，TG和LDH的水平以及心脏体重比。与对照组相比，CPA给药后，ROS参数显示丙二醛（MDA）显着增加（P <0.05），谷胱甘肽（GSH）和超氧化物歧化酶（SOD）显着降低（PO.05）。与CPA组相比，CPA注射后Vit.C或橄榄油的施用显着降低了MDA的水平（P <0.05），并且GSH和SOD的水平均显着提高了（P <0.05）。目前的数据显示，Vit.C和橄榄油的使用改善了注射CPA的大鼠的心脏组织病理学变化。这些发现表明，Vit.C和橄榄油可以用作动物体内有效的自由基清除剂，以最大程度地降低抗癌药治疗的毒性作用。

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