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首页> 外文期刊>Journal of cosmetic and laser therapy >Reversal of photodamage with topical growth factors: a pilot study.
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Reversal of photodamage with topical growth factors: a pilot study.

机译：用局部生长因子逆转光损伤：一项初步研究。

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BACKGROUND: Interest in the reversal of facial photodamage has increased significantly among patients and physicians in the past decade. Though surgical procedures may be very effective, the associated healing time and potential risks have spurred the development of non-surgical treatments. There has also been an increasing depth of knowledge regarding wound healing and its control by growth factors as well as its modulation by the topical application of growth factors. Bioengineered tissue cultures have resulted in the ability to collect naturally occurring human growth factors in their tissue concentrations. OBJECTIVE: The objective of this study is to determine if the twice daily application of a combination of multiple growth factors to photodamaged facial skin results in any evidence of improvement after 60 days. METHODS: Fourteen patients applied a gel containing a mixture of eight different growth factors (Nouricel-MD) to photodamaged facial skin twice daily. Prior to the study and at days therewere clinical evaluations of photodamage (Fitzpatrick scale), 3 mm punch biopsies and optical profilometry. Patient questionnaires were answered at 60 days. RESULTS: Eleven of 14 patients showed clinical improvement in at least one facial area. The peri-orbital region showed a statistically significant improvement (p = 0.0003). Optical profilometry showed a statistically significant reduction in Ra measurement (p=0.0075) and shadowing (p=0.02), both indicating a decrease in the depth and number of textural irregularities or fine lines. Biopsies revealed new collagen formation in the Grenz zone (37% increase in thickness) and thickening of the epidermis by 27%. Eight of 14 patients felt their wrinkles were improved, while 12 of 14 felt their skin texture was improved. CONCLUSIONS: The application of a mixture of topical growth factors may stimulate the repair of facial photodamage resulting in new collagen formation, epidermal thickening and the clinical appearance of smoother skin with less visible wrinkling.
机译：背景：在过去的十年中，患者和医师对面部光损伤逆转的兴趣显着增加。尽管外科手术可能非常有效，但相关的治愈时间和潜在风险刺激了非外科治疗的发展。关于伤口愈合及其通过生长因子的控制以及通过局部应用生长因子的调节的知识的深度也越来越广。生物工程化的组织培养物具有收集组织浓度中天然存在的人类生长因子的能力。目的：本研究的目的是确定60天后，每天两次将多种生长因子组合用于光损伤的面部皮肤是否能导致任何改善的迹象。方法：十四名患者每天两次将含有八种不同生长因子（Nouricel-MD）混合物的凝胶涂在光损伤的面部皮肤上。在研究之前和几天，对光损伤（Fitzpatrick标度），3毫米打孔活组织检查和光学轮廓测定法进行临床评估。在60天时回答了患者问卷。结果：14名患者中有11名在至少一个面部区域表现出临床改善。眼眶周围区域显示出统计学上的显着改善（p = 0.0003）。光学轮廓测定法显示Ra测量值（p = 0.0075）和阴影（p = 0.02）在统计学上显着降低，均表明纹理不规则或细线的深度和数量减少。活组织检查显示在Grenz区有新的胶原蛋白形成（厚度增加了37％），表皮增厚了27％。 14位患者中有8位感觉皱纹得到改善，而14位患者中有12位感觉皮肤纹理得到改善。结论：局部生长因子混合物的应用可能刺激面部光损伤的修复，从而导致新的胶原蛋白形成，表皮增厚以及皮肤较光滑，皱纹较少的临床外观。

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