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首页> 外文期刊>Journal of endotoxin research >The nexus between systemic inflammation and disordered coagulation in sepsis.
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The nexus between systemic inflammation and disordered coagulation in sepsis.

机译：脓毒症中全身性炎症与凝血功能紊乱之间的联系。

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摘要

The innate immune system is designed as an early defense system that recognizes and clears potential microbial invaders. The coagulation system co-evolved with the innate immune system from a common ancestral cellular origin, and these two systems continue to exhibit a remarkable degree of integration in their signaling pathways and regulatory circuits following tissue injury and microbial invasion. Inflammatory mediators generate procoagulant signals and intravascular thrombosis activates multiple components of the innate immune system. The success of recombinant human activated protein C for the treatment of human septic shock is likely attributable to its combined effects as an endogenous anticoagulant and an anti-inflammatory molecule. Further advances in the management of severe infections may accrue with a better understanding of the integral link between coagulation and innate immunity.
机译：先天免疫系统被设计为一种早期防御系统，可以识别和清除潜在的微生物入侵者。凝血系统与先天免疫系统共同起源于祖先细胞，这两个系统在组织损伤和微生物入侵后，在其信号传导途径和调节回路中继续表现出显着的整合。炎性介质产生促凝血信号，血管内血栓形成激活先天免疫系统的多个组成部分。重组人活化蛋白C在治疗人败血症性休克中的成功可能归因于其作为内源性抗凝剂和抗炎分子的综合作用。严重感染管理的进一步进展可能会更好地理解凝血与先天免疫之间的内在联系。

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