...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of endotoxin research >Toll and Toll-9 in Drosophila innate immune response.
【24h】

Toll and Toll-9 in Drosophila innate immune response.

机译：果蝇中的Toll和Toll-9具有先天免疫反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In both insects and mammals, members of the Toll receptor family play important roles in the initial events leading to the activation of immunity genes. The prototypic Toll in Drosophila appears to be activated by a host protein ligand after microbial stimulation. The cellular events and the biological response after Toll activation, however, require further investigation. We used transgenic Drosophila strains expressing NF-kappaB and Toll proteins to investigate innate immune response in whole larvae and dissected larval fat bodies. Substantial activation of antimicrobial peptide genes was observed after septic injury. To circumvent the contribution of injury-induced response, we used dissected larval fat bodies to show that commercially available microbial compounds were able to alter the cellular distribution of Toll. The results also demonstrate that complex cellular events, including receptor trafficking, likely take place after stimulation of the larval immune tissue. By genome-wide expression analysis, we further show that Toll and Toll-9 may utilize the same signaling pathway in activating many immunity genes. Thus, the innate immune response in Drosophila is regulated by complex mechanisms, which involve Toll and other Toll-related proteins.
机译：在昆虫和哺乳动物中，Toll受体家族的成员在导致免疫基因激活的初始事件中都起着重要作用。果蝇中的原型Toll似乎在微生物刺激后被宿主蛋白配体激活。然而，激活Toll后的细胞事件和生物学反应需要进一步研究。我们使用表达NF-kappaB和Toll蛋白的转基因果蝇菌株调查整个幼虫和解剖的幼虫脂肪体内的先天免疫应答。败血性损伤后观察到抗菌肽基因的大量激活。为了规避损伤诱导的反应的贡献，我们使用解剖的幼虫脂肪体来证明市售微生物化合物能够改变Toll的细胞分布。结果还表明，刺激幼虫免疫组织后可能发生复杂的细胞事件，包括受体运输。通过全基因组表达分析，我们进一步表明，Toll和Toll-9在激活许多免疫基因中可能利用相同的信号通路。因此，果蝇的先天免疫反应受复杂机制的调控，这些机制涉及Toll和其他与Toll相关的蛋白质。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号