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首页> 外文期刊>Journal of enzyme inhibition >Inhibition of pig liver and Zea mays L. polyamine oxidase: a comparative study.
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Inhibition of pig liver and Zea mays L. polyamine oxidase: a comparative study.

机译：猪肝和玉米玉米多胺氧化酶的抑制作用：一项比较研究。

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摘要

Polyamine oxidase (PAO) is involved in polyamine metabolism and production of hydrogen peroxide in animal and plants, thus representing a key system in development and programmed cell death. In the present study, the inhibitory effect of amiloride, p-aminobenzamidine, clonidine, 4',6-diamidino-2-phenyl-indole (DAPI), gabexate mesylate, guazatine, and N,N'-bis(2,3-butadienyl)-1,4-butane-diamine (MDL72527) on the catalytic activity of pig liver and Zea mays L. PAO, Lens culinaris L. and Pisum sativum L. and swine kidney copper amine oxidase, bovine trypsin, as well as neuronal constitutive nitric oxide synthase (NOS-I) was investigated. Moreover, agmatine and N(3) -prenylagmatine (G3) were observed to inhibit pig liver and Zea mays L. PAO, bovine trypsin, and NOS-I action, but were substrates for Lens culinaris L., Pisum sativum L. and swine kidney copper amine oxidase. Guazatine and G3 inhibited selectively Zea mays L. PAO with K(i) values of 7.5 x 10(-9) M and 1.5 x 10(-8) M, respectively (at pH 6.5 and 25.0 degrees C). As a whole, the data reported here represent examples of enzyme cross-inhibition, and appear to be relevant in view of the use of cationic L-arginine-and imidazole-based compounds as drugs.
机译：多胺氧化酶（PAO）参与动植物中多胺的代谢和过氧化氢的产生，因此代表了发育和程序性细胞死亡的关键系统。在本研究中，阿米洛利，对氨基苯甲m，可乐定，4'，6-二mid基-2-苯基-吲哚（DAPI），甲磺酸加贝酯，guazatine和N，N'-bis（2,3-丁二烯基）-1,4-丁烷二胺（MDL72527）对猪肝和玉米（Zea mays L.PAO），扁豆（Lens culinaris L.）和小豌豆（Pisum sativum L.），猪肾铜胺氧化酶，牛胰蛋白酶以及神经元的催化活性研究了组成型一氧化氮合酶（NOS-1）。此外，观察到胍丁胺和N（3-）-prenylagmatine（G3）抑制猪肝和玉米（Zea mays L.）PAO，牛胰蛋白酶和NOS-1的作用，但它们是片状Lens culinaris L.，Pisum sativum L.和猪的底物。肾脏铜胺氧化酶。 guazatine和G3选择性抑制玉米（Zea mays L. PAO），其K（i）值分别为7.5 x 10（-9）M和1.5 x 10（-8）M（在pH 6.5和25.0摄氏度下）。总体而言，此处报道的数据代表酶交叉抑制的实例，考虑到使用阳离子L-精氨酸和咪唑类化合物作为药物，这些数据似乎具有相关性。

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