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首页> 外文期刊>Journal of Equine Veterinary Science >Effect of Platelet-Rich Plasma-Incorporated Gelatin Hydrogel Microspheres and Subchondral Drilling on Equine Cartilage Defects
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Effect of Platelet-Rich Plasma-Incorporated Gelatin Hydrogel Microspheres and Subchondral Drilling on Equine Cartilage Defects

机译：富含血小板的血浆明胶水凝胶微球和软骨下钻孔对马软骨缺损的影响

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摘要

We evaluated the effect of platelet-rich plasma-incorporated gelatin hydrogel microsphere (PRP/GM) together with subchondral drilling for cartilage regeneration in horses. Cartilage defects (diameter, 4.5 mm; depth, 3.0 mm) were created in both third carpal bones of six Thoroughbred horses. A subchondral hole was drilled at the center of this cartilage defect (diameter, 2.0 mm; depth, 35 mm) in one randomly selected carpal joint (test joint), whereas no subchondral hole was made in the contralateral joint (control joint). Thereafter, the test joint was injected with PRP/GM and the control joint with saline-infused GM. Additional injections of PRP/GM were given 14 and 28 days after surgery. After 16 weeks, histologic analysis was conducted. The macroscopic and histologic scores of the test group were significantly higher than those of the control group (P .05). These data indicated that the application of PRP/GM together with subchondral drilling accelerated cartilage regeneration in horses
机译：我们评估了富含血小板的血浆结合明胶水凝胶微球（PRP / GM）以及软骨下钻孔对马软骨再生的影响。在六匹纯种马的两个第三腕骨中都形成了软骨缺损（直径4.5毫米;深度3.0毫米）。在一个随机选择的腕关节（测试关节）的该软骨缺损的中心（直径2.0毫米;深度35毫米）处钻出软骨下孔，而对侧关节（对照关节）未制作软骨下孔。此后，向测试关节注射PRP / GM，向对照关节注射盐水。手术后14和28天再注射一次PRP / GM。 16周后，进行组织学分析。试验组的宏观和组织学评分明显高于对照组（P <.05）。这些数据表明，PRP / GM与软骨下钻孔的结合可加速马的软骨再生。

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