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首页> 外文期刊>Journal of geriatric psychiatry and neurology >Genetics and dementia nosology.
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Genetics and dementia nosology.

机译：遗传学和痴呆症学。

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摘要

In preparation for the development of the Diagnostic and Statistical Manual of Mental Disorders (5th ed), the American Psychiatric Association convened workshops reviewing scientific evidence relevant to diagnosis of dementia. One of the domains covered was genetics, which is reviewed here. The following areas are reviewed: genetic data on Alzheimer's disease and other dementias; the impact of nosology on genetic research in terms of its potential to improve diagnostic sensitivity and specificity and to decrease heterogeneity; the impact of genetic research findings on nosology, specific diagnostic criteria, and subtypes; and recommendations and future directions. The focus is on Alzheimer's disease, where more genetic data are available, and other dementias are reviewed more briefly. In addition, a separate section reviews the relationship of genetic findings and mild cognitive impairment, a boundary zone between normal aging and dementia, particularly Alzheimer's disease.
机译：为了准备《精神疾病诊断和统计手册》（第5版），美国精神病学协会召开了研讨会，对与痴呆症诊断有关的科学证据进行了审查。涉及的领域之一是遗传学，在此进行综述。审查了以下领域：阿尔茨海默氏病和其他痴呆症的遗传数据;就改善诊断敏感性和特异性以及减少异质性的潜力而言，疾病学对遗传研究的影响;基因研究结果对疾病学，特定诊断标准和亚型的影响;以及建议和未来方向。重点是阿尔茨海默氏病，该病可获得更多的遗传数据，而其他痴呆症的综述则更为简短。另外，一个单独的部分回顾了遗传学发现与轻度认知障碍之间的关系，轻度认知障碍是正常衰老与痴呆症（尤其是阿尔茨海默氏病）之间的边界区域。

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