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首页> 外文期刊>Journal of geriatric psychiatry and neurology >Symptoms underlying unawareness of memory impairment in patients with mild Alzheimer's disease.
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Symptoms underlying unawareness of memory impairment in patients with mild Alzheimer's disease.

机译：轻度阿尔茨海默氏病患者无意识记忆障碍的症状。

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Patients with Alzheimer's disease (AD) are often unaware of their cognitive impairment. This unawareness might have a multifactorial etiology, including impairment of cognitive domains and psychiatric symptoms. We conducted this study to determine the factors underlying unawareness of memory impairment (UMI) in patients with AD. In 103 patients with mild AD, the UMI was quantified as the difference between the patient's self-rating and the rating of the patient's caregiver on a standardized memory questionnaire system, the Everyday Memory Checklist. We then examined the relationships between UMI and memory, attention, language, visuospatial/constructive perception, frontal lobe function, and psychiatric symptoms. UMI was positively associated with memory impairment and delusions when effects of age, sex, and education were partialled out, suggesting that these symptoms are involved in the formation of UMI in the patients. Thus, existing treatments for memory impairment and delusions may be beneficial for increasing the awareness of mild AD patients of their cognitive impairment.
机译：患有阿尔茨海默氏病（AD）的患者通常不了解其认知障碍。这种不了解可能是多方面的病因，包括认知域和精神病症状的损害。我们进行了这项研究，以确定AD患者不了解记忆障碍（UMI）的潜在因素。在103名轻度AD患者中，UMI被量化为患者的自我评价与照料者的评价之间的差异，这是通过标准化的记忆问卷系统“日常记忆检查表”进行的。然后，我们检查了UMI与记忆力，注意力，语言，视觉空间/建设性知觉，额叶功能和精神病症状之间的关系。当年龄，性别和教育程度的影响被部分消除时，UMI与记忆障碍和妄想呈正相关，表明这些症状与患者UMI的形成有关。因此，现有的记忆力减退和妄想疗法可能有益于增加轻度AD患者对其认知力减退的认识。

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