...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical Pharmacology and Therapeutics >Effect of ranitidine on the pharmacokinetics of triazolam and alpha-hydroxytriazolam in both young (19-60 years) and older (61-78 years) people.
【24h】

Effect of ranitidine on the pharmacokinetics of triazolam and alpha-hydroxytriazolam in both young (19-60 years) and older (61-78 years) people.

机译：雷尼替丁对年轻人（19-60岁）和老年人（61-78岁）中三唑仑和α-羟基三唑仑药代动力学的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: This study evaluated the effect of oral ranitidine (75 mg and 150 mg) on the pharmacokinetics of triazolam (0.25 mg) and its major metabolite, alpha-hydroxytriazolam, in both young and older people. Metabolite data were used to distinguish the mechanism of this interaction. METHOD: This was a randomized, open-label, 3-way crossover study. Eighteen young (19-60 years) and 12 older (61-78 years) men and women were randomly assigned to receive evening doses of triazolam 0.25 mg (1) alone, (2) on the third day of dosing ranitidine 75 mg twice daily for 4 days, and (3) on the third day of dosing ranitidine 150 mg twice daily for 4 days. RESULTS: In the young group, mean triazolam area under the concentration-time curve from time zero to infinity [AUC(0-infinity)] was 10% and 28% higher after treatment with 75 mg and 150 mg ranitidine, respectively. In the older group, mean triazolam AUC(0-infinity) was 31% and 28% higher after treatment with 75 mg and 150 mg ranitidine, respectively. There was no change in the alpha-hydroxytriazolam/triazolam AUC(0-infinity) ratio in either age group, indicating that neither formation nor elimination of alpha-hydroxytriazolam was affected by ranitidine. There were no changes in the half-life of triazolam or alpha-hydroxytriazolam. CONCLUSION: Ranitidine increases oral absorption of triazolam in both young and older people. This effect is likely caused by elevation of gastrointestinal pH, allowing for greater absorption of acid-labile triazolam. The difference in this effect between age groups at the lower 75-mg dose of ranitidine suggests that older people may be more sensitive to the antisecretory effect of ranitidine.
机译：目的：本研究评估了口服雷尼替丁（75毫克和150毫克）对三唑仑（0.25毫克）及其主要代谢产物α-羟基三唑仑在年轻人和老年人中的药代动力学的影响。代谢物数据用于区分这种相互作用的机制。方法：这是一项随机，开放标签，三向交叉研究。随机分配18名年轻人（19-60岁）和12名年龄较大（61-78岁）的男性和女性，他们分别接受晚上两次剂量的雷尼替丁75 mg的第三天晚上服用0.25 mg三唑仑（1），（2）持续4天，以及（3）在第3天每天服用雷尼替丁150 mg两次，持续4天。结果：在年轻组中，用75 mg和150 mg雷尼替丁治疗后，从时间零到无穷[AUC（0-infinity）]的浓度-时间曲线下的平均三唑仑面积分别增加了10％和28％。在老年组中，用75 mg和150 mg雷尼替丁治疗后，平均三唑仑AUC（0-无穷大）分别高31％和28％。任一年龄组的α-羟基三唑仑/三唑仑AUC（0-无穷大）比率均无变化，表明雷尼替丁既不影响α-羟基三唑仑的形成也不消除。三唑仑或α-羟基三唑仑的半衰期没有变化。结论：雷尼替丁可增加年轻人和老年人口服三唑仑的吸收。这种作用很可能是由于胃肠道pH升高引起的，从而使对酸不稳定的三唑仑的吸收更大。在较低剂量的雷尼替丁75毫克剂量下，不同年龄组之间的这种作用差异表明，老年人可能对雷尼替丁的抗分泌作用更为敏感。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号