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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >WHO international cytokine standards and reference preparations.
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WHO international cytokine standards and reference preparations.

机译:世卫组织国际细胞因子标准和参考制剂。

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摘要

The ability to quantify the activity of cytokines is an essential part of experimental and clinical investigation and is to a large extent dependent on the availability of suitable cytokine standards and reference reagents. The ISICR Standards Committee was established 2 decades ago to make recommendations regarding IFN and cytokine standards and standardization to the ISICR membership and thereby, to the international cytokine scientific community. The committee works closely with the WHO, the NIBSC, die U.S. National Institutes of Health, die Biodefense and Emerging Infections Resources Repository, pharmaceutical manufacturers and regulatory agencies. The committee includes members from several of these organizations. Current topics under analysis by die committee include die establishment of appropriate standards for biosimilars, pe-gylated biopharmaceuticals, and antibodies directed against protein-based drugs.
机译:量化细胞因子活性的能力是实验和临床研究的重要组成部分,并且在很大程度上取决于合适的细胞因子标准品和参考试剂的可用性。 ISICR标准委员会成立于20年前,旨在为ISICR成员以及国际细胞因子科学界就IFN和细胞因子标准和标准化提出建议。该委员会与WHO,NIBSC,美国国立卫生研究院,生物防御和新兴感染资源库,制药商和监管机构密切合作。该委员会包括来自这些组织中的几个的成员。该委员会正在分析的当前主题包括建立适用于生物仿制药,聚乙二醇化生物药物和针对基于蛋白质的药物的抗体的适当标准。

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