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首页> 外文期刊>Journal of Macromolecular Science. Pure and Applied Chemistry >Formulation and Evaluation of 5-FU Loaded Eudragit Microspheres: Effect of Various Eudragit on Micromeretic Properties of Microspheres
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Formulation and Evaluation of 5-FU Loaded Eudragit Microspheres: Effect of Various Eudragit on Micromeretic Properties of Microspheres

机译：5-FU负载的Eudragit微球的配制和评估：各种Eudragit对微球微细化性能的影响

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摘要

The aim of the present study was to prepare and evaluate microspheres of Eudragit (RS, RL and RSPO) containing an anticancer drug 5-FU. Microspheres were prepared by O/O solvent evaporation method using a acetone/liquid paraffin system. Magnesium stearate was used as the droplet stabilizer and n-hexane was added to harden the microspheres. The prepared microspheres were characterized for theirmicromeretic properties and entrapment efficiency; as well by Fourier transforminfrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), thin layer chromatography (TLC) and scanning electron microscopy (SEM) revealed the crystalline nature of drug in a final state. The in vitro release studies were performed in a Phosphate Buffer Solution (PBS) pH 7.4. The best fit release kinetics was achieved with a Higuchi plot. The yields of preparation and entrapment efficiencies were very high with a larger particle size for all the formulations. Mean particle size, entrapment efficiency and production yield were highly influenced by the type of polymer and polymer concentration. It is concluded from the present investigation that various Eudragit are promising controlled release carriers for 5-FU.
机译：本研究的目的是制备和评估含有抗癌药物5-FU的Eudragit（RS，RL和RSPO）微球。通过使用丙酮/液体石蜡系统的O / O溶剂蒸发法制备微球。硬脂酸镁用作液滴稳定剂，并添加正己烷以硬化微球。所制备的微球的微球性质和包封效率被表征。以及通过傅立叶变换红外光谱（FTIR），差示扫描量热法（DSC），X射线粉末衍射法（XRPD），薄层色谱法（TLC）和扫描电子显微镜（SEM）揭示了最终状态下药物的结晶性质。体外释放研究是在pH 7.4的磷酸盐缓冲溶液（PBS）中进行的。用Higuchi曲线可以得到最佳的贴合释放动力学。对于所有制剂而言，制备的产率和截留效率非常高，而粒径较大。平均粒径，截留效率和生产收率受聚合物类型和聚合物浓度的很大影响。从本研究得出结论，各种Eudragit是有前途的5-FU控释载体。

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