• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology >Interleukin-10 promoter polymorphisms in myasthenia gravis
【24h】

Interleukin-10 promoter polymorphisms in myasthenia gravis

机译：重症肌无力中白细胞介素10启动子多态性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Interleukin 10 (IL-10) is secreted by several hemopoietic cells and suppresses the Thl mediated immune response, while stimulating B cell differentiation and the humoral immune response. IL-10 expression in Con A-stimulated peripheral blood mononuclear cells is related to three polymorphisms in the promoter region of the IL-10 gene; G/A at position -1082, T/C at position - 819 and A/C at position - 592. We analyzed the distribution of these IL-10 polymorphisms in 64 MG patients and 87 healthy blood donors to determine any influence on MG susceptibility. MG patients had a significantly higher frequency of the ACC/ACC haplotype (12.5% vs 3.4% in controls), as had the subgroups with late onset MG and thymomatous MG (20.0% and 21.4%, respectively). Early onset MG patients had a high frequency of the ATA/ATA haplotype (19.2% vs 3.4% in controls). Titin Ab-positive MG patients had high ACC/ACC (20.0%). This study indicates a direct link between IL-10 and MG pathogenesis, although the complex role of this multi-faceted cytokine in vivo is as yet not fully elucidated.
机译：白细胞介素10（IL-10）由几种造血细胞分泌，抑制Th1介导的免疫反应，同时刺激B细胞分化和体液免疫反应。 Con A刺激的外周血单个核细胞中IL-10的表达与IL-10基因启动子区域的三种多态性有关。 G / A在位置-1082，T / C在位置-819和A / C在位置-592。我们分析了这些IL-10多态性在64名MG患者和87位健康献血者中的分布，以确定对MG敏感性的任何影响。 MG患者的ACC / ACC单倍型频率显着更高（12.5％vs对照组的3.4％），晚期MG和胸腺MG的亚组（分别为20.0％和21.4％）。早期发作的MG患者的ATA / ATA单倍型频率较高（19.2％比对照组的3.4％）。 Titin Ab阳性MG患者的ACC / ACC较高（20.0％）。这项研究表明IL-10和MG发病机制之间的直接联系，尽管这种多方面的细胞因子在体内的复杂作用尚未完全阐明。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号