...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Spray-dried microspheres containing ketoprofen formulated into capsules and tablets
【24h】

Spray-dried microspheres containing ketoprofen formulated into capsules and tablets

机译：含有酮洛芬的喷雾干燥微球剂被制成胶囊和片剂

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study, microspheres were prepared by a spray-drying technique using solutions of ketoprofen and two polymers, cellulose acetate butyrate (CAB) and hydroypropylmethylcellulose phthalate (HPMCP), in different weight ratios. Different total concentrations were used in the feed solutions: 3, 6 and 9% w/v. The spray-dried microparticles were characterized in terms of shape (SEM), size (light scattering method), production yield and encapsulation efficiency. They were formulated into capsules; tablets were prepared by direct com-pression of the microparticles mixed with maltose and, in some cases, hydro-ypropylmethylcellulose (HPMC). In vitro release studies were performed both at acidic and neutral pHs. The spray-drying process of solutions of ketoprofen with polymeric blends of cellulose derivatives leads to microparticles which, depending on their final formulation (capsules or tablets), can give a rapid or prolonged drug release. The formulations here described can be proposed for the oral administration of NSAIDs.
机译：在这项研究中，通过喷雾干燥技术使用酮洛芬和两种聚合物（丁酸纤维素乙酸酯（CAB）和羟丙基甲基纤维素邻苯二甲酸酯（HPMCP））的不同重量比溶液制备微球。进料溶液中使用了不同的总浓度：3％，6％和9％w / v。通过形状（SEM），尺寸（光散射法），生产产率和包封效率来表征喷雾干燥的微粒。他们被制成胶囊;通过直接压制与麦芽糖和在某些情况下为羟丙基甲基纤维素（HPMC）混合的微粒制备片剂。在酸性和中性pH下都进行了体外释放研究。酮洛芬溶液与纤维素衍生物的聚合物共混物的喷雾干燥过程会产生微粒，取决于它们的最终配方（胶囊或片剂），它们可以使药物快速释放或延长释放时间。可以将本文所述的制剂用于NSAID的口服给药。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号