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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Urea-formaldehyde nanocapsules for the controlled release of diclofenac sodium
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Urea-formaldehyde nanocapsules for the controlled release of diclofenac sodium

机译：脲醛纳米胶囊用于双氯芬酸钠的控释

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摘要

Urea-formaldehyde (UF), polymerized in situ in aqueous media, is a rigid polymer that can be used in the controlled release of bioactive molecules. During the process of polymerization, liquid neem seed oil (NSO) was encapsulated at three different loadings, which was then replaced by diclofenac sodium (DS), the presence of which was confirmed by FTIR spectra. The nanocapsules thus prepared were evaluated for percentage loading of the drug, particle size and release characteristics. Thermal analysis and x-ray data were obtained to understand the physical nature of the encapsulated drug. The surfac characteristics of thenanocapsules were studied using a scanning electron microscope. Particles in the size range around 500nm were obtained. The percentage loading efficiency of NSO was approx 90-95, whereas for DS, the loading efficiency was only 50-60%. Complete release of the drug from the matrices occurred in 24 h, whereas, at 8 h only 60% of the drug was released.
机译：在水性介质中原位聚合的脲甲醛（UF）是一种刚性聚合物，可用于控制释放生物活性分子。在聚合过程中，将液态印seed种子油（NSO）封装在三个不同的装填量中，然后用双氯芬酸钠（DS）代替，并通过FTIR光谱证实了其存在。评价由此制备的纳米胶囊的药物装载百分比，粒度和释放特性。获得热分析和X射线数据以了解所包封药物的物理性质。然后使用扫描电子显微镜研究了纳米胶囊的表面特征。获得尺寸范围为约500nm的颗粒。 NSO的百分比加载效率约为90-95，而DS的加载效率仅为50-60％。药物从基质完全释放发生在24小时内，而在8小时内仅释放了60％的药物。

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