Mophological changes in degrading PLGA and P(DL)LA microspheres: implications for the design of controlled release systems

N.Badri Viswanathan; S.S.Patil; J.K.Pandit

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Mophological changes in degrading PLGA and P(DL)LA microspheres: implications for the design of controlled release systems

机译：降解PLGA和P（DL）LA微球的形态变化：对控释系统设计的启示

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The in vitro degradation of microspheres of lactic and glycolic acids were investigated by monitoring the mass loss from the device, the molecular weight of the polymer and the morphological changes of he particles with time

机译：通过监测装置的质量损失，聚合物的分子量以及颗粒随时间的形态变化，研究了乳酸和乙醇酸微球的体外降解。

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《Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres》 |2001年第6期|共18页
作者
N.Badri Viswanathan; S.S.Patil; J.K.Pandit;
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原文格式 PDF
正文语种 eng
中图分类药剂学;
关键词
biodegradable polymers; poly(DL)-lactic acid; degradation; release mehanism; pulsed; sustained release;

机译：生物可降解聚合物;聚（DL）-乳酸;降解;释放机理;脉冲;持续释放;

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1. Mophological changes in degrading PLGA and P(DL)LA microspheres: implications for the design of controlled release systems [J] . N.Badri Viswanathan, S.S.Patil, J.K.Pandit Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres . 2001,第6期

机译：降解PLGA和P（DL）LA微球的形态变化：对控释系统设计的启示
2. In vitro degradation and controlled release behavior of D,L-PLGA50 and PCL-b-D,L-PLGA50 copolymer microspheres [J] . Dong CM, Guo YZ, Qiu KY, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2005,第1期

机译：D，L-PLGA50和PCL-b-D，L-PLGA50共聚物微球的体外降解和控释行为
3. Development of chondroitin sulfate encapsulated PLGA microsphere delivery systems with controllable multiple burst releases for treating osteoarthritis. [J] . Jiang T, Petersen RR, Call G, Journal of biomedical materials research. Part B, Applied biomaterials. . 2011,第2期

机译：硫酸软骨素封装的PLGA微球递送系统的开发，该系统具有可控的多次爆发释放，可用于治疗骨关节炎。
4. Degradation-controlled release of BSA from microspheres of hydroxylated PLGA [C] . A. H. Ghassemi, M. J. van Steenbergen, H. Talsma, Annual meeting exposition of the Controlled Release Society . 2011

机译：从羟基化PLGA微球中降解控制释放BSA
5. Development of controlled release microspheres for targeted drug delivery system using camptothecin as a model drug: An in vitro-in vivo correlation. [D] . Sonavaria, Vandana Jeewandas. 1994

机译：使用喜树碱作为模型药物开发靶向药物释放系统的控释微球：体内外相关性。
6. Controlled Release of Octreotide and Assessment of Peptide Acylation from Poly(DL-lactide-co-hydroxymethyl glycolide) Compared to PLGA Microspheres [O] . Amir H. Ghassemi, Mies J. van Steenbergen, Arjan Barendregt, -1

机译：与PLGA微球相比奥曲肽的控制释放和聚（DL-丙交酯-共羟甲基乙交酯）肽酰化的评估
7. Core/shell PLGA microspheres with controllable in vivo release profile via rational core phase design [O] . Meiling Yu, Qing Yao, Yan Zhang, 2018

机译：核心/壳壳PLGA微球，通过理性核心相位设计可控制体内释放曲线

Mophological changes in degrading PLGA and P(DL)LA microspheres: implications for the design of controlled release systems

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