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首页> 外文期刊>Journal of neurology >Risk factors, aetiology and outcome of ischaemic stroke in young adults: the Swiss Young Stroke Study (SYSS)
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Risk factors, aetiology and outcome of ischaemic stroke in young adults: the Swiss Young Stroke Study (SYSS)

机译：青年人中风的危险因素，病因和结局：瑞士年轻中风研究（SYSS）

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摘要

Ischaemic stroke (IS) in young adults has been increasingly recognized as a serious health condition. Stroke aetiology is different in young adults than in the older population. This study aimed to investigate aetiology and risk factors, and to search for predictors of outcome and recurrence in young IS patients. We conducted a prospective multicentre study of consecutive IS patients aged 16-55 years. Baseline demographic data, risk factors, stroke aetiology including systematic genetic screening for Fabry disease and severity were assessed and related to functional neurological outcome (modified Rankin Scale, mRS), case fatality, employment status, place of residence, and recurrent cerebrovascular events at 3 months. In 624 IS patients (60 % men), median age was 46 (IQR 39-51) years and median NIHSS on admission 3 (IQR 1-8). Modifiable vascular risk factors were found in 73 %. Stroke aetiology was mostly cardioembolism (32 %) and of other defined origin (24 %), including cervicocerebral artery dissection (17 %). Fabry disease was diagnosed in 2 patients (0.3 %). Aetiology remained unknown in 20 %. Outcome at 3 months was favourable (mRS 0-1) in 61 % and fatal in 2.9 %. Stroke severity (p<0.001) and diabetes mellitus (p = 0.023) predicted unfavourable outcome. Stroke recurrence rate at 3 months was 2.7 %. Previous stroke or TIA predicted recurrent cerebrovascular events (p = 0.012). In conclusion, most young adults with IS had modifiable vascular risk factors, emphasizing the importance of prevention strategies. Outcome was unfavourable in more than a third of patients and was associated with initial stroke severity and diabetes mellitus. Previous cerebrovascular events predicted recurrent ones.
机译：年轻人的缺血性中风（IS）已被越来越多地视为一种严重的健康状况。年轻人的卒中病因学与老年人群不同。这项研究旨在调查病因和危险因素，并寻找年轻IS患者结局和复发的预测指标。我们对连续16至55岁的IS患者进行了一项前瞻性多中心研究。评估了基线人口统计学数据，危险因素，中风病因，包括对法布里疾病和严重性进行系统的遗传筛查，并与功能性神经学结局（改良的兰金量表，mRS），病死率，就业状况，居住地和脑血管复发相关个月。在624名IS患者（男性占60％）中，中位年龄为46岁（IQR 39-51）岁，入院3时中位NIHSS（IQR 1-8）。发现可改变的血管危险因素占73％。中风的病因主要是心脏栓塞（32％）和其他明确的起源（24％），包括颈脑动脉夹层（17％）。法布里病被诊断出2例（0.3％）。病因学仍未知，占20％。 3个月时的结果良好（mRS 0-1）为61％，致命的为2.9％。中风严重度（p <0.001）和糖尿病（p = 0.023）预测不良结果。 3个月时中风复发率为2.7％。先前的卒中或TIA预测脑血管复发事件（p = 0.012）。总之，大多数IS患者具有可改变的血管危险因素，强调了预防策略的重要性。超过三分之一的患者结局不利，并与初始卒中严重程度和糖尿病有关。先前的脑血管事件预示着复发。

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