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首页> 外文期刊>Journal of neurology >A case of eosinophilic meningitis in Germany.
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A case of eosinophilic meningitis in Germany.

机译：德国一例嗜酸性脑膜炎。

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Sirs: A 36 year-old German female had a history of fluctuating, increasing headache, abnormal fatigue and recurrent slight fever over 6 months, 3 months after she had been to Thailand.Physical examination revealed meningism as the only pathological sign. Differential blood cell count showed an increased number of eosinophils (12 %). IgE level was elevated. Repeated electroencephalographies and spinal and cerebral contrast enhanced MRI were unremarkable. Two lumbar punctures performed at one month intervals revealed 200 to 300 leucocytes per microliter, predominantly eosino-philic cells, a slightly elevated protein level (55 mg/dl) and blood-CSF barrier dysfunction. The immunoblot for Angiostrongylus cantonensis performed at the Department of Helminthology at Mahidol University in Bangkok was positive (Fig. 1) as well as the ELISA for toxocariasis at the Department of Infectious Diseases and Tropical Medicine at Ludwig-Maximilians-Universitat in Munich. Infection with Borrelia burgdorferi, Treponema pallidum, human immunodeficiency virus, other helminths and fungi and Plasmodium falciparum were excluded by serological tests and blood film microscopy. No findings supported the diagnosis of vasculitis or indicated haematological malignancy.
机译：主席先生：一位36岁的德国女性在去泰国3个月后的6个月内有起伏，头痛增加，异常疲劳和反复发烧的病史。体检显示脑膜炎是唯一的病理征象。差异血细胞计数显示嗜酸性粒细胞数量增加（12％）。 IgE水平升高。反复进行脑电图检查以及脊柱和脑部造影增强MRI均无统计学意义。每隔一个月进行两次腰椎穿刺，发现每微升200至300个白细胞，主要是嗜酸性细胞，蛋白质水平略微升高（55 mg / dl），血液CSF屏障功能障碍。曼谷玛希顿大学的蠕虫学系进行的广州血管圆线虫的免疫印迹呈阳性（图1），慕尼黑路德维希-马克西米利安斯大学传染病与热带医学系的弓形虫病ELISA呈阳性。血清学检查和血膜显微镜检查排除了伯氏疏螺旋体，梅毒螺旋体，人免疫缺陷病毒，其他蠕虫和真菌以及恶性疟原虫的感染。没有发现支持血管炎或血液系统恶性肿瘤的诊断。

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