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Immunotherapy for melanoma.

机译:黑色素瘤的免疫疗法。

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摘要

The immunogenicity of melanoma and the identification of melanoma-associated antigens is the basis for immunotherapy. This review will discuss the current status of melanoma immunotherapy with a focus on non-specific cytokines and highly specific vaccines, including peptides, viruses, dendritic cells, and whole cell vaccines. The passive transfer of melanoma-specific monoclonal antibodies and T-cells will also be reviewed. The problem of tumor escape and the association of immunotherapy to autoimmunity will be discussed. The use of immunotherapy in combination with other therapeutic agents and genetic profiling to predict responses suggests that immunotherapy will continue to play a role in the treatment of melanoma.
机译:黑色素瘤的免疫原性和黑色素瘤相关抗原的鉴定是免疫治疗的基础。这篇综述将讨论黑色素瘤免疫治疗的现状,重点是非特异性细胞因子和高度特异性的疫苗,包括肽,病毒,树突状细胞和全细胞疫苗。黑色素瘤特异性单克隆抗体和T细胞的被动转移也将被审查。将讨论肿瘤逃逸的问题以及免疫疗法与自身免疫的关系。将免疫疗法与其他治疗剂和基因分析结合使用以预测反应,表明免疫疗法将继续在黑色素瘤的治疗中发挥作用。

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