Melanoma genetics: The other side

BisS.; TsaoH.

首页> 外文期刊>Clinics in dermatology >Melanoma genetics: The other side

【24h】

Melanoma genetics: The other side

机译：黑色素瘤遗传学：另一面

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Although melanoma has traditionally been regarded as a uniformly fatal malignancy, personalized treatment of this cancer relies on the recognition of its genetic heterogeneity and our ability to pharmacologically target these specific and recurrent changes. Recent advances in the treatment of melanoma have come from the understanding that melanoma is a large family of molecularly distinct diseases. Advances in melanoma genetics and new molecular technology, such as whole-exome and whole-genome sequencing, have lead to unprecedented progress in understanding the key oncogenes and signaling pathways involved in the pathogenesis and progression of melanoma. In addition, we have gained an appreciation for the complexity of such a system with numerous points of cross talk, which has partially impeded our current therapeutic strategies in patients with advanced melanoma. In this review, we focus on the novel discoveries in melanoma genetics and the potential for therapeutic options. ? 2013.

机译：尽管传统上将黑素瘤视为一种致命的恶性肿瘤，但对这种癌症的个性化治疗依赖于其遗传异质性的认识以及我们以药理学针对这些特定和复发性变化的能力。黑色素瘤的治疗方面的最新进展来自对黑色素瘤是一大类分子不同的疾病的认识。黑色素瘤遗传学和新分子技术（例如全外显子组和全基因组测序）的进步已导致在了解与黑色素瘤的发病机理和进展有关的关键癌基因和信号传导途径方面取得了空前的进展。此外，我们对这种具有众多串扰点的系统的复杂性表示赞赏，这部分地阻碍了我们目前对晚期黑素瘤患者的治疗策略。在这篇综述中，我们专注于黑色素瘤遗传学的新发现以及治疗选择的潜力。？ 2013。

著录项

来源
《Clinics in dermatology》 |2013年第2期|共8页
作者
BisS.; TsaoH.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类皮肤病学与性病学;
关键词

相似文献

外文文献
中文文献
专利

1. Counseling and DNA testing for individuals perceived to be genetically predisposed to melanoma: A consensus statement of the Melanoma Genetics Consortium. [J] . Kefford RF, Newton Bishop-JA, Bergman W, Journal of Clinical Oncology . 1999,第10期

机译：对被认为是遗传易患黑色素瘤的个体的咨询和DNA测试：黑色素瘤遗传学联盟的共识声明。
2. Whole cell melanoma vaccine genetically modified to stem cells like phenotype generates specific immune responses to ALDH1A1 and long-term survival in advanced melanoma patients [J] . Eliza Kwiatkowska-Borowczyk, Patrycja Czerwinska, Jacek Mackiewicz, Oncoimmunology. . 2018,第11期

机译：全细胞黑色素瘤疫苗遗传修饰为干细胞，如表型对Aldh1a1产生特异性免疫应答，以及晚期黑素瘤患者的长期存活
3. The absence of multiple atypical nevi in germline CDKN2A mutations: Comment on "Hereditary melanoma: Update on syndromes and management: Genetics of familial atypical multiple mole melanoma syndrome'' [J] . Ipenburg Norbertus Anton, Gruis Nelleke A., Bergman Wilma, Journal of the American Academy of Dermatology . 2016,第4期

机译：种系CDKN2A突变中不存在多发性非典型痣：评论“遗传性黑色素瘤：综合征和治疗的最新进展：家族性非典型多痣黑素瘤综合征的遗传学”
4. Fusion of Color Bands Using Genetic Algorithm to Segment Melanoma [C] . Rafael L Araújo, Daniela M Ushizima, Romuere R V Silva International Symposium on Biomedical Imaging Workshops . 2020

机译：遗传算法融合彩色带分割黑色素瘤
5. Evaluating targeted and immunomodulatory therapies for melanoma in a genetically engineered mouse melanoma model. [D] . Lockhart, Billy J. 2015

机译：在基因工程小鼠黑色素瘤模型中评估黑色素瘤的靶向和免疫调节疗法。
6. Conjunctival Melanoma: Genetic and Epigenetic Insights of a Distinct Type of Melanoma [O] . Ernesto Rossi, Giovanni Schinzari, Brigida Anna Maiorano, 2019

机译：结膜黑色素瘤：不同类型黑色素瘤的遗传和表观遗传学见解
7. Whole cell melanoma vaccine genetically modified to stem cells like phenotype generates specific immune responses to ALDH1A1 and long-term survival in advanced melanoma patients [O] . Eliza Kwiatkowska-Borowczyk, Patrycja Czerwińska, Jacek Mackiewicz, 2018

机译：全细胞黑色素瘤疫苗遗传修饰为干细胞，如表型为Aldh1a1的特异性免疫应答和晚期黑素瘤患者的长期存活

Melanoma genetics: The other side

摘要

著录项

相似文献

相关主题

期刊订阅