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首页> 外文期刊>Clinics in dermatology >Comorbidities in psoriasis.
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Comorbidities in psoriasis.

机译：牛皮癣合并症。

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Epidemiological studies have shown that, in psoriasis patients, associated disorders may occur more frequently than expected. Such comorbidities include psoriatic arthritis, psoriatic pustular diseases, Crohn disease, and signs of metabolic syndrome, which leads to atherosclerosis with coronary heart disease. Although the disorders represent separate entities, they appear to follow overlapping pathogenic pathways. Comorbidities often become clinically manifest years after onset of psoriasis and are frequently seen in severe disease. Persistent low-grade inflammation with secretion of proinflammatory cytokines (eg, tumor necrosis factor alpha) favors the development of insulin resistance and metabolic syndrome. In addition, biochemical and immunologic observations point toward an inflammatory immune mechanism that uses tools of the innate defense armamentarium.
机译：流行病学研究表明，在牛皮癣患者中，相关疾病的发生频率可能​​比预期的高。此类合并症包括牛皮癣关节炎，牛皮癣脓疱病，克罗恩病和代谢综合征的体征，后者导致冠心病的动脉粥样硬化。尽管这些疾病代表不同的实体，但它们似乎遵循重叠的致病途径。合并症通常在牛皮癣发作数年后在临床上表现出来，并在严重疾病中经常见到。具有促炎细胞因子（例如肿瘤坏死因子α）分泌的持续性低度炎症有助于胰岛素抵抗和代谢综合征的发展。另外，生化和免疫学观察结果指向使用先天防御武器库的工具的炎性免疫机制。

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