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首页> 外文期刊>Clinics in dermatology >Immunopathogenesis of sarcoidosis.
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Immunopathogenesis of sarcoidosis.

机译：结节病的免疫发病机制。

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摘要

The immunopathogenesis of sarcoidosis has been difficult to charaterize given the heterogeneity of disease, the elusiveness of the causative antigen, and the lack of an adequate animal model. However, by examining well-defined clinical cohorts, the interplay between genetic predisposition and immunologic response has been increasingly informative. Technological advances in cellular analysis have allowed researchers to characterize the immune responses important in the maintenance of granulomatous inflammation. Finally, "new" clinical observations such as granuloma responsiveness to targeted biological therapies, sarcoid developing during immune restoration, and the relationship between sarcoidosis and Hepatitis C will provide future insight to the immunopathogenesis of sarcoidosis.
机译：鉴于疾病的异质性，致病性抗原的可捉摸性以及缺乏适当的动物模型，结节病的免疫发病机制很难表征。然而，通过检查明确的临床队列，遗传易感性与免疫应答之间的相互作用已越来越有用。细胞分析技术的进步使研究人员能够表征对维持肉芽肿性炎症至关重要的免疫反应。最后，“新的”临床观察，例如肉芽肿对靶向生物疗法的反应性，免疫修复期间结节状的发展以及结节病与丙型肝炎之间的关系，将为结节病的免疫发病机理提供未来的见识。

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