• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of pharmacology & toxicology. >alpha-Glucosidase Inhibitor Activity of Terminalia Species
【24h】

alpha-Glucosidase Inhibitor Activity of Terminalia Species

机译：榄仁属物种的α-葡萄糖苷酶抑制剂活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Terminalia arjuna, Terminalia ballerica, Terminalia chebula, Terminalia catappa, Terminalia kaerbachii and Terminalia microcarpa leaves were tested for their a-glucosidase inhibitory activity in vitro. The a-glucosidase activity was determined by measuring the p-nitrophenol release from pNPG at 400 rim. Terminalia kaerbachii has the highest a-glucosidase inhibitor activity with IC_50value of 0.27+-0.17 jag mL~-1 and is a promising antidiabetic herbal medicine candidate. However, most of the Terminalia species are also potential as antidiabetic medicine candidates as the IC_50 values are approximately 5 ug mL~-1, which is near the IC_50 value of 1-deoxynojirimycin, the reference compound, except for Terminalia microcarpa, which has IC_50 value of 25.15+-0.04 ug mL~-1 (above 21 mug mL~-1). From the phytochemical screening, Terminalia kaerbacchi contains alkaloids, flavonoids and cathechic tannins, but does not contain saponin, quinon, steroid/terpenoids and gallic tannins.
机译：在体外测试了榄仁（Terminalia arjuna），榄仁榄仁（Terminalia ballerica），白头榄仁（Terminalia chebula），卡特彼勒榄仁（Terminalia catappa），卡氏榄仁（Terminalia kaerbachii）和小果榄仁（Terminalia microcarpa）叶片的α-葡糖苷酶抑制活性。 α-葡糖苷酶活性是通过在400边缘测量从pNPG释放的对硝基苯酚来确定的。喀山榄仁（Terminalia kaerbachii）具有最高的α-葡萄糖苷酶抑制剂活性，IC_50值为0.27 + -0.17 jag mL〜-1，是一种有希望的抗糖尿病草药。但是，大多数榄仁木属植物也具有潜在的抗糖尿病作用，因为IC_50值约为5 ug mL〜-1，与参考化合物1-脱氧野oji霉素的IC_50值相近，除了榄仁木具有IC_50的情况。值为25.15 + -0.04 ug mL〜-1（高于21杯mL〜-1）。通过植物化学筛选，Terminalia kaerbacchi包含生物碱，类黄酮和钙鞣质，但不包含皂苷，醌，类固醇/萜类和没食子鞣质。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号