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首页> 外文期刊>Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland >What is Burkitt's lymphoma?
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What is Burkitt's lymphoma?

机译：什么是伯基特氏淋巴瘤？

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Burkitt's lymphoma (BL) has been defined on the basis of its characteristic cytomorphology. Although histologically identical, endemic BL and sporadic BL are distinct clinico-anatomical entities. Their morphological identity probably relates to similar chromosomal translocations in both tumours, resulting in c-myc de-regulation and consequent unrestrained proliferation without differentiation. Similar gene rearrangements are found in a proportion of AIDS-related lymphomas that are predominantly extranodal and have the cytomorphology of BL. The term "Burkitt-like lymphoma" (BLL) has been applied to a group of high-grade B-cell lymphomas that appear morphologically intermediate between BL and centroblastic/immunoblastic lymphomas, as detailed in an accompanying paper in this issue. These tumours do not usually show c-myc gene rearrangements. The association of Burkitt's name with such a disparate group of tumours is confusing and new terminology for sporadic BL, AIDS-related BL and BLL is desirable. It is important that clinico-anatomical features, as well as cytomorphology, should be taken into account in the diagnosis of endemic BL. The origin of a case from tropical Africa does not, in itself, imply that it is endemic BL, even more since the AIDS epidemic in that continent.
机译：Burkitt淋巴瘤（BL）已根据其特征性细胞形态学进行了定义。尽管组织学上相同，但地方性BL和散发性BL是不同的临床解剖实体。它们的形态同一性可能与两个肿瘤中类似的染色体易位有关，导致c-myc失调并因此不受限制地增殖而没有分化。在一部分与艾滋病相关的淋巴瘤中发现了相似的基因重排，这些淋巴瘤主要是结节外的并且具有BL的细胞形态。术语“伯基特样淋巴瘤”（BLL）已应用于一组在形态学上介于BL与中心粒细胞/免疫母细胞淋巴瘤之间的高级别B细胞淋巴瘤，如本期随附论文中所述。这些肿瘤通常不显示c-myc基因重排。 Burkitt的名字与如此不​​同的肿瘤群的联系令人困惑，因此零星的BL，与艾滋病相关的BL和BLL的新术语是可取的。重要的是在诊断地方性BL时应考虑临床解剖特征以及细胞形态。病例来自热带非洲本身并不意味着它是地方性流行病，甚至更是如此，因为该大陆的艾滋病流行。

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