The thymus and central tolerance.

Kishimoto H; Sprent J

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The thymus and central tolerance.

机译：胸腺和中枢耐受。

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T cell tolerance to self-components occurs largely in the thymus during early differentiation and leads to death (negative selection) of T cells with overt autoreactivity. In this article we review the evidence that negative selection in mice occurs mainly in the medulla at the level of a population of semimature T cells. The role of Fas and several costimulatory molecules on negative selection and the inhibitory role of certain cytokines are discussed. Copyright 2000 Academic Press.

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《Clinical immunology: The official journal of the Clinical Immunology Society》 |2000年第2期|共9页
作者
Kishimoto H; Sprent J;
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正文语种 eng
中图分类医学免疫学;
关键词
Cerebral Cortex; Thymus Gland; 大脑皮质; 胸腺;

机译：Cerebral Cortex;Thymus Gland;大脑皮质;胸腺;

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2. Aberrant expression of tissue-specific proteins in the thymus: a hypothesis for the development of central tolerance. [J] . Werdelin O, Cordes U, Jensen T Scandinavian journal of immunology. . 1998,第2期

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3. Role of the thymus in transplantation tolerance in miniature Swine: IV. The thymus is required during the induction phase, but not the maintenance phase, of renal allograft tolerance. [J] . Vagefi PA, Ierino FL, Gianello PR, Transplantation: Official Journal of the Transplantation Society . 2004,第7期

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4. Democracy as Tolerance. People Exercising a Different Kind of Power in a Global World [C] . Maxim S.T. International Conference LUMEN . 2014

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5. Critical roles for somatic hypermutation and TLR signaling in the development of B cell central tolerance. [D] . McDonald, Gabrielle. 2016

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6. The thymus and central tolerance. [O] . J Sprent, H Kishimoto 2001

机译：胸腺和中枢耐受。
7. The thymus and central tolerance. [O] . Sprent, J, Kishimoto, H 2001

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8. Ionizing Radiation and the Thymus. Effects of Whole-Body Irradiation with Fast Fission Neutrons and X-Rays on the Murine Thymus [R] . Huiskamp, R. 1986

机译：电离辐射与胸腺。快速裂变中子和X射线全身照射对小鼠胸腺的影响

The thymus and central tolerance.

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