MDR1A (ABCB1)-deficient CF-1 mutant mice are susceptible to cerebral malaria induced by Plasmodium berghei ANKA

de Lagerie SB; Fernandez C; German-Fattal M; Gantier JC; Gimenez F; Farinotti R

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MDR1A (ABCB1)-deficient CF-1 mutant mice are susceptible to cerebral malaria induced by Plasmodium berghei ANKA

机译：MDR1A（ABCB1）缺陷的CF-1突变小鼠易患伯氏疟原虫ANKA诱发的脑疟疾

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Under experimental conditions, Plasmodium berghei infection causes cerebral malaria (CM) in susceptible strains of mice such as C57BL/6 and CBA/Ca, whereas BALB/c or DBA/2J strains serve as a model for CM-resistant mice. The aim of the present study was to investigate the susceptibility of the CF1 mouse strain, carrying a spontaneous mutation of the mdr1a gene, to infection with Plasmodium berghei ANKA (PbA). The mdr1a gene codes for P-glycoprotein (P-gp/ABCB1), an efflux pump that is one of the major components of the blood-brain barrier. P-gp effluxes a broad range of xenobiotics from the brain to blood, preventing accumulation and toxicity in the central nervous system. CFI mdr1a (-/-) mice are used to investigate drug transport by efflux pumps. Because many antimalarial agents are effluxed by P-gp (mefloquine, quinine), it was important to determine whether CF1 mice can develop cerebral malaria to predict drug toxicity during cerebral malaria. Our work showed that CF1 mdr1a (-/-) mice are susceptible to PbA. CF1 and C57BL/6N mice (the reference strain) infected with PbA have similar profiles with regard to clinical signs, brain histological lesions, and brain macrophagic activation observed by immunohistological methods.

机译：在实验条件下，伯氏疟原虫感染会在易感小鼠品系（如C57BL / 6和CBA / Ca）中引起脑疟疾，而BALB / c或DBA / 2J品系可作为CM抗性小鼠的模型。本研究的目的是研究携带mdr1a基因自发突变的CF1小鼠品系感染伯氏疟原虫ANKA（PbA）的敏感性。 mdr1a基因编码P-糖蛋白（P-gp / ABCB1），P-糖蛋白是一种外排泵，是血脑屏障的主要成分之一。 P-gp可排出从大脑到血液的多种异生素，从而防止中枢神经系统中的蓄积和毒性。 CFI mdr1a（-/-）小鼠用于研究外排泵的药物转运。由于P-gp（甲氟喹，奎宁）会释放出许多抗疟药，因此确定CF1小鼠是否会发展为脑疟疾以预测在脑疟疾期间的药物毒性非常重要。我们的工作表明CF1 mdr1a（-/-）小鼠对PbA敏感。通过免疫组织学方法观察到的感染PbA的CF1和C57BL / 6N小鼠（参考株）在临床体征，脑组织病变和脑巨噬细胞活化方面具有相似的特征。

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《Journal of Parasitology》 |2008年第5期|共4页
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de Lagerie SB; Fernandez C; German-Fattal M; Gantier JC; Gimenez F; Farinotti R;
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中图分类寄生生物学;医学寄生虫学;
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1. MDR1A (ABCB1)-Deficient CF-1 Mutant Mice are Susceptible to Cerebral Malaria Induced by Plasmodium Berghei ANKA [J] . Sylvie Barraud de Lagerie Christine Fernandez Michèle German-Fattal Jean-Charles Gantier François Gimenez and Robert Farinotti Journal of Parasitology . 2008,第5期

机译：MDR1A（ABCB1）缺陷型CF-1突变小鼠易患疟原虫Banghei ANKA诱发的脑疟疾
2. Age-Related CD4+CD25+Foxp3+ Regulatory T-Cell Responses During Plasmodium berghei ANKA Infection in Mice Susceptible or Resistant to Cerebral Malaria [J] . Ying Shan, Jun Liu, Yan-Yan Pan, The Korean Journal of Parasitology . 2013,第3期

机译：伯氏疟原虫ANKA感染易感或抗脑疟疾的小鼠中与年龄相关的CD4 + CD25 + Foxp3 +调节性T细胞反应。
3. Age-Related CD4+CD25+Foxp3+ Regulatory T-Cell Responses During Plasmodium berghei ANKA Infection in Mice Susceptible or Resistant to Cerebral Malaria [J] . Shan Ying, Liu Jun, Pan Yan-Yan, The Korean Journal of Parasitology . 2013,第3期

机译：伯氏疟原虫ANKA感染对脑疟疾敏感或抵抗的小鼠中与年龄有关的CD4 + CD25 + Foxp3 + 调节性T细胞反应
4. Interplay between the Gut Epithelium, Intestinal Microflora and the Local Immune Response in Inflammatory Bowel Disease: Lessons to be Learnt from Mdr1a Deficient Mice. [C] . Jo Viney Annual Meeting of the American Society for Veterinary Clinical Pathology . 2003

机译：肠道上皮，肠道微生物，炎症性肠病疾病中的局部免疫反应之间的相互作用：从MDR1A缺乏小鼠中学到的课程。
5. 1. Generation and characterization of mutants in the proteolytic processing site of the circumsporozoite protein (CSP) of Plasmodium berghei. 2. Fluorescent Plasmodium berghei sporozoites and pre-erythrocytic stages: A new tool to study mosquito and mammalian host interactions with malaria parasites. [D] . Natarajan, Ramya. 2006

机译：1.伯氏疟原虫环子孢子蛋白（CSP）的蛋白水解加工位点中突变体的产生和表征。 2.伯氏疟原虫子孢子荧光体和促红细胞生成前阶段：研究蚊子和哺乳动物宿主与疟原虫相互作用的新工具。
6. Age-Related CD4+CD25+Foxp3+ Regulatory T-Cell Responses During Plasmodium berghei ANKA Infection in Mice Susceptible or Resistant to Cerebral Malaria [O] . Ying Shan, Jun Liu, Yan-Yan Pan, 2013

机译：伯氏疟原虫ANKA感染易感或抗脑疟疾的小鼠中与年龄相关的CD4 + CD25 + Foxp3 +调节性T细胞反应。
7. Cytokine and chemokine responses in a cerebral malaria-susceptible or -resistant strain of mice to Plasmodium berghei ANKA infection: early chemokine expression in the brain [O] . S. Hanum P. 2003

机译：细胞因子和趋化因子在脑疟疾中对小鼠的敏感或 - Berghei Anka感染感染的脑敏感或致癌菌株：大脑中的早期趋化因子表达
8. 'Plasmodium berghei berghei': Irradiated Sporozoites of the ANKA Strain as Immunizing Antigens in Mice. [R] . Beaudoin, R. L., Strome, C. P. A., Tubergen, T. A., 1975

机译：'伯氏疟原虫'：aNKa株的辐照子孢子作为小鼠免疫抗原。

MDR1A (ABCB1)-deficient CF-1 mutant mice are susceptible to cerebral malaria induced by Plasmodium berghei ANKA

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