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首页> 外文期刊>Journal of Solution Chemistry >Thermodynamic Quantities for the Different Steps Involved in the Oxidation of the Drug Ketorolac by Copper(III) Periodate Complex in Aqueous Alkaline Medium: A Mechanistic Approach
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Thermodynamic Quantities for the Different Steps Involved in the Oxidation of the Drug Ketorolac by Copper(III) Periodate Complex in Aqueous Alkaline Medium: A Mechanistic Approach

机译：碱性介质中高碘酸铜（III）络合物在药物酮咯酸氧化过程中涉及的不同步骤的热力学量：一种机械方法

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摘要

The oxidation of ketorolac (KET) by diperiodatocuprate(III) (DPC) in aqueous alkaline medium at a constant ionic strength of 0.10 mola <...dm(-3) was studied spectrophotometrically at 298 K. The reaction is of first order in [DPC] and has less than unit order in both [KET] and [alkali], and negative fractional order in [periodate]. The oxidation reaction in alkaline medium has been shown to proceed via a DPC-ketorolac complex, which decomposes slowly in a rate determining step followed by other fast steps to give the products. The main products were identified by spot test, IR and GC-MS spectral studies. The reaction constants involved in the different steps of the mechanism were calculated at different temperatures, which yielded thermodynamic quantities for different steps of the reaction scheme. The activation parameters with respect to the slow step of the mechanism were computed and discussed; thermodynamic quantities were also determined.
机译：在298 K下用分光光度法研究了在碱性水介质中，恒定离子强度为0.10 mola <... dm（-3）时，二酮戊二酸铜（III）（DPC）对酮咯酸（KET）的氧化作用。 [DPC]在[KET]和[碱]中均小于单位阶，在[高碘酸盐]中具有负分数阶。已显示在碱性介质中的氧化反应是通过DPC-酮咯酸络合物进行的，该络合物在速率测定步骤中缓慢分解，然后在其他快速步骤中分解，得到产物。主要产品通过现场测试，IR和GC-MS光谱研究进行鉴定。在不同温度下计算了该机理的不同步骤所涉及的反应常数，从而得出了反应方案不同步骤的热力学量。计算并讨论了与该机构的慢步有关的激活参数;还确定了热力学量。

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