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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Characteristics of Wake-up stroke
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Characteristics of Wake-up stroke

机译：唤醒行程的特征

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Background Wake-up stroke (WUS) accounts for up to 29.6% of ischemic strokes, but its mechanisms are poorly understood. The purpose of this study is to identify risk factors and characteristics of WUS. Methods Seven-two ischemic strokes were classified as WUS or non-WUS. Collected were demographic information, medical history, cholesterol profile, and stroke characteristics including severity (National Institutes of Health Stroke Scale [NIHSS]) and mechanism (Trial of Org 10172 in Acute Stroke Treatment criteria). Subjects completed questionnaires screening for sleep apnea (Berlin questionnaire) and assessing sleep characteristics. Results There were 72 ischemic strokes, of which 28 WUS (38.9%). WUS and non-WUS patients were similar in regard to stroke risk factors. WUS patients tended to be African American and were significantly younger. WUS was significantly more likely to result from small-vessel disease mechanism (42.9% versus 14.0%; P =.006) and tended to be less severe WUS (NIHSS score 3 [1, 4] versus 4 [2, 11]; P =.13) than non-WUS. Groups did not differ in regard to scoring positively on the Berlin questionnaire, but WUS sufferers were more likely to snore frequently (90.5% versus 70.0%, P =.08). The lipid profile was significantly worse in WUS compared with non-WUS (low-density lipoprotein 124.6 ± 38.4 versus 103.7 ± 36.8; P =.03; cholesterol to high-density lipoprotein ratio 5.2 ± 1.6 versus 4.3 ± 1.6; P =.02). Conclusions WUS is more likely to result from small-vessel disease mechanism. Poorer cholesterol profile and frequent snoring may contribute to WUS.
机译：背景唤醒性中风（WUS）占缺血性中风的比例高达29.6％，但其机制尚不清楚。这项研究的目的是确定WUS的危险因素和特征。方法将72例缺血性卒中分为WUS或非WUS。收集了人口统计学信息，病史，胆固醇谱以及中风特征，包括严重程度（美国国立卫生研究院中风量表[NIHSS]）和机制（急性中风治疗标准的Org 10172试验）。受试者完成了针对睡眠呼吸暂停的问卷调查（柏林问卷），并评估了睡眠特征。结果共发生缺血性卒中72例，其中WUS 28例，占38.9％。 WUS和非WUS患者在中风危险因素方面相似。 WUS患者倾向于非裔美国人，而且年龄明显年轻。 WUS更有可能是由小血管疾病机制引起的（42.9％对14.0％; P = .006），并且倾向较轻（WHO评分较轻（NIHSS评分3 [1，4]对4 [2，11]）; P = .13）。在柏林问卷调查中，各组在积极评分方面没有差异，但WUS患者打sn的可能性更高（90.5％对70.0％，P = .08）。与非WUS相比，WUS中的脂质状况明显较差（低密度脂蛋白124.6±38.4对103.7±36.8; P = 0.03;胆固醇与高密度脂蛋白之比5.2±1.6对4.3±1.6; P = .02 ）。结论WUS更有可能是由小血管疾病机制引起的。较差的胆固醇状况和频繁打呼may可能会导致WUS。

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