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首页> 外文期刊>Journal of the Brazilian Chemical Society >Bioactive flavonoids and triterpenes from Terminalia fagifolia (Combretaceae)
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Bioactive flavonoids and triterpenes from Terminalia fagifolia (Combretaceae)

机译：榄仁（Combretaceae）的生物活性类黄酮和三萜

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摘要

Two 1,3-diarylpropanes, 1-(4'-hydroxy-2'-methoxyphenyl)-3-(3"-methoxy-4"-hydroxyphenyl)- propane and 1-(2'-hydroxy-4',6'-dimethoxyphenyl)-3-(3"- methoxy-4"-hydroxyphenyl)-propane, seven flavanones, naringenin, naringenin-4',7-dimethyl-ether, sakuranetin, isosakuranetin, liquiritigenin-4', 7- dimethyl-ether, liquiritigenin-7-methyl-ether and liquiritigenin-4'-methyl-ether, two chalcones, isoliquiritigenin-4-methyl-ether and isoliquiritigenin-4'-methyl- ether, one flavan, 7,4'-dihydroxy-3'-methoxyflavan, nine triterpenes, arjunic acid, arjunetin, arjungenin, arjunglucoside I, arjunolic acid, arjunglucoside II, 23-galloylarjunglucoside II (isolated as its mono-, di- and tri-O-methyl derivatives after methylation with diazomethane), betulinic acid and ursolic acid acetate, along with gallic acid and sitosterol were isolated from the heartwood and trunk bark of of Terminalia fagifolia. The flavanones and chalcones obtained in the present work are new in the Combretaceae and this is the first report of the occurrence of 1,3-diarylpropanes in this family. The isolated compounds were evaluated for their in vitro cytotoxic activity against two human cancer cell lines (Hep 2 larynx carcinoma and H 292 lung mucoepidermoid carcinoma) and antioxidant properties. Isoliquiritigenin-4-methylether, isoliquiritigenin-4'-methyl- ether, 1-(2'-hydroxy-4',6'-dimethoxyphenyl)-3-(3"-methoxy4"- hydroxyphenyl)-propane and the di- and tri-O-methyl derivatives of 23-galloylarjunglucoside II were the most active in the cytotoxic assay.
机译：两个1,3-二芳基丙烷，1-（4'-羟基-2'-甲氧基苯基）-3-（3“-甲氧基-4”-羟基苯基）-丙烷和1-（2'-羟基-4'，6' -二甲氧基苯基）-3-（3“-甲氧基-4”-羟基苯基）-丙烷，七个黄烷酮，柚皮苷，柚皮苷-4'，7-二甲基醚，樱草苷，异樱草苷，liquiritigenin-4'，7-二甲基醚，liquiritigenin-7-甲基醚和liquiritigenin-4'-甲基醚，两个查耳酮，异quiritigenin-4-甲基醚和isoquiritigenin-4'-甲基醚，一个黄烷，7,4'-二羟基-3' -甲氧基黄烷，九个三萜，阿魏酸，arjunetin，arjungenin，阿糖苷I，阿糖酸，阿糖苷II，23-半乳糖苷葡糖苷II（在重氮甲烷甲基化后分离为其单，二和三O-甲基衍生物），桦木酸从Terminalia fagifolia的心材和树干树皮中分离出乙酸和熊果酸乙酸，没食子酸和谷甾醇。在目前的工作中获得的黄烷酮和查耳酮是菊科中的新成员，这是该家族中1,3-二芳基丙烷的首次报道。评估分离出的化合物对两种人类癌细胞系（Hep 2喉癌和H 292肺粘液表皮样癌）的体外细胞毒性活性和抗氧化特性。异黄体生成素-4-甲基醚，异黄体生成素-4'-甲基醚，1-（2'-羟基-4'，6'-二甲氧基苯基）-3-（3“-甲氧基4”-羟基苯基）-丙烷和二和23-galloylarjunglucoglucoside II的三-O-甲基衍生物在细胞毒性测定中最活跃。

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