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首页> 外文期刊>Journal of the Brazilian Chemical Society >A fast fluorimetric flow injection method to determine ibuprofen
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A fast fluorimetric flow injection method to determine ibuprofen

机译:快速荧光流动注射法测定布洛芬

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摘要

The native fluorescence of ibuprofen was enhanced when a host-guest complex of the analyte with beta cyclodextrin (beta-CD) was formed. So, based on this fact, a flow injection method to determine ibuprofen in different pharmaceutical preparations with fluorescence detection (lambda(em) 287 nm, lambda(exc) 223 nm) was developed. The calibration curve was linear over the range 6.00 - 60.0 mg L-1 of ibuprofen and the detection limit (LOD) for S/N=3 was 4.5 mg L-1. The relative standard deviation was 1.2% and the sample throughput 240 h(-1). The method was validated by comparing the proposed and the official method to commercial preparation samples.
机译:当分析物与β-环糊精(β-CD)形成宿主-客体复合物时,布洛芬的天然荧光增强。因此,基于此事实,开发了一种流动注射法,通过荧光检测(lambda(em)287 nm,lambda(exc)223 nm)来测定不同药物制剂中的布洛芬。校准曲线在布洛芬6.00-60.0 mg L-1范围内呈线性,并且S / N = 3的检出限(LOD)为4.5 mg L-1。相对标准偏差为1.2%,样品通量为240 h(-1)。通过比较建议的方法和正式方法与商业制备样品进行了验证。

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