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首页> 外文期刊>Clinical neurology and neurosurgery >The predictive value of the presence of different antibodies and thymus pathology to the clinical outcome in patients with generalized myasthenia gravis
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The predictive value of the presence of different antibodies and thymus pathology to the clinical outcome in patients with generalized myasthenia gravis

机译：广义重症肌无力患者中不同抗体和胸腺病理学的存在对临床结果的预测价值

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Objectives: To analyze the predictive value of anti-acetylcholine receptor antibodies (anti-AChR Ab) and anti-muscle specific kinase antibodies (anti-MuSK Ab), as well as the thymus pathology to the clinical outcome in patients with generalized myasthenia gravis (MG). Methods: We analyzed 138 patients with generalized MG, who were thymectomized and assayed for anti-AChR Ab and anti-MuSK Ab. Results: Anti-AChR Ab were detected in 84% of patients, while anti-MuSK Ab were present in 36% of the AChR Ab negative patients. Severe forms of the disease were more frequent in MuSK Ab positive, compared to the AChR Ab positive and complete seronegative patients. Thymic lymphoid follicular hyperplasia (LFH) was present in 60%, thymoma in 23%, atrophic thymus in 9% and the normal thymus in 8% of patients. LFH was more frequent among women, while thymoma and atrophic thymus were more frequent in men. The younger patients mainly had LFH and normal thymus, while thymoma and atrophic thymus were more frequent in older patients. The mildest clinical presentation was present in patients with normal thymus, while severe forms of the disease were registered in the patients with thymoma. The AChR Ab positive patients had more often LFH and thymoma, while within MuSK Ab positive patients atrophic thymus was most common. Conclusion: The best disease outcome was observed in patients with normal thymus or LFH with anti-AChR Ab or without both types of antibodies.
机译：目的：分析抗乙酰胆碱受体抗体（anti-AChR Ab）和抗肌肉特异性激酶抗体（anti-MuSK Ab）的预测价值，以及胸腺病理对重症肌无力患者的临床结局（ MG）。方法：我们分析了138例经胸腺切除的广义MG患者，并分析了其抗AChR抗体和抗MuSK抗体的水平。结果：在84％的患者中检测到抗AChR Ab抗体，而在36％的AChR Ab阴性患者中检测到抗MuSK Ab抗体。与AChR Ab阳性和完全血清阴性的患者相比，MuSK Ab阳性的严重形式的疾病更为常见。胸腺淋巴滤泡性增生（LFH）占60％，胸腺瘤占23％，萎缩性胸腺占9％，正常胸腺占8％。 LFH在女性中更为频繁，而胸腺瘤和萎缩性胸腺在男性中更为频繁。较年轻的患者主要有LFH和正常的胸腺，而老年患者的胸腺瘤和萎缩性胸腺更为常见。胸腺正常的患者中临床表现最温和，胸腺瘤患者中存在严重的疾病。 AChR Ab阳性患者更常发生LFH和胸腺瘤，而在MuSK Ab阳性患者中萎缩性胸腺最为常见。结论：在具有抗AChR Ab或无两种抗体的正常胸腺或LFH患者中观察到最佳疾病结局。

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