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Molecular evolution of catalysis

机译：催化的分子进化

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In this paper, we consider the evolutionary dynamics of catalytically active species with a distinct genotype-phenotype relationship. Folding landscapes of RNA molecules serve as a paradigm for this relationship with essential neutral properties. The landscape itself is partitioned by phenotypes (realized as RNA secondary structures). To each genotype (represented as a sequence) a structure is assigned in a unique way. The set of all sequences which map into a particular structure is modeled as a random graph in sequence space (the so-called neutral network). A catalytic network is realized as a random digraph with maximal out-degree two and secondary structures as vertex sets. A population of catalytic RNA molecules shows significantly different behavior compared to a deterministic description: hypercycles are able to co-exist and out-compete a parasite with superior catalytic support. A "switching" between different dynamic organizations of the network can be observed, dynamical stability of hypercyclic organizations against errors and the existence of an error-threshold of catalysis can be reported. (C) 2000 Academic Press. [References: 72]
机译：在本文中，我们考虑具有明显的基因型-表型关系的催化活性物种的进化动力学。 RNA分子的折叠态作为具有基本中性特性的这种关系的范例。景观本身被表型（实现为RNA二级结构）划分。对于每种基因型（表示为序列），都以唯一的方式分配结构。映射到特定结构中的所有序列的集合被建模为序列空间中的随机图（所谓的中性网络）。催化网络被实现为具有最大向外度二级和二级结构为顶点集的随机有向图。与确定性描述相比，催化RNA分子种群表现出显着不同的行为：超环能够与上等催化支持物共存并竞争。可以观察到网络的不同动态组织之间的“切换”，可以报告超环组织对错误的动力学稳定性以及催化错误阈值的存在。 （C）2000学术出版社。 [参考：72]

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