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首页> 外文期刊>Journal of toxicology and environmental health, Part B. Critical reviews >The added value of proteomics for toxicological studies
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The added value of proteomics for toxicological studies

机译：蛋白质组学在毒理学研究中的附加价值

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摘要

Proteomics has the potential to elucidate complex patterns of toxic action attributed to its unique holistic a posteriori approach. In the case of toxic compounds for which the mechanism of action is not completely understood, a proteomic approach may provide valuable mechanistic insight. This review provides an overview of currently available proteomic techniques, including examples of their application in toxicological in vivo and in vitro studies. Future perspectives for a wider application of state-of-the-art proteomic techniques in the field of toxicology are discussed. The examples concern experiments with dioxins, polychlorinated biphenyls, and polybrominated diphenyl ethers as model compounds, as they exhibit a plethora of sublethal effects, of which some mechanisms were revealed via successful proteomic studies. Generally, this review shows the added value of including proteomics in a modern tool box for toxicological studies.
机译：蛋白质组学有可能阐明其独特的整体后验方法引起的复杂的毒性作用模式。对于尚不完全了解其作用机理的有毒化合物，蛋白质组学方法可能会提供有价值的机理见解。这篇综述概述了目前可用的蛋白质组学技术，包括其在体内和体外毒理学研究中的应用实例。讨论了在毒理学领域广泛应用最新蛋白质组学技术的未来前景。实施例涉及以二恶英，多氯联苯和多溴联苯醚为模型化合物的实验，因为它们表现出大量的亚致死作用，其中一些机制通过成功的蛋白质组学研究得以揭示。通常，此评论显示了在毒理学研究的现代工具箱中包含蛋白质组学的附加价值。

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