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首页> 外文期刊>Journal of Toxicology-Toxin Reviews >ANCROD: A POTENTIAL TREATMENT FOR ACUTE, ISCHEMIC STROKE FROM SNAKE VENOM
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ANCROD: A POTENTIAL TREATMENT FOR ACUTE, ISCHEMIC STROKE FROM SNAKE VENOM

机译：止痛药：蛇毒急性缺血性中风的潜在治疗方法

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摘要

The direct effect of ancrod is defibrinogenation. This results in several secondary effects that differentiate ancrod from typical thrombolytics such as rt-PA. The combined actions of indirect fibrinolysis, reduced fibrin deposition, and decreased blood viscosity represent a constellation of actions that should be beneficial in a variety of thrombotic conditions. The clinical condition explored most thoroughly in recent years with ancrod has been its acute application to ischemic stroke. Two clinical studies (one of them with a 6 h time-to-treatment window) have demonstrated significant benefit in increasing the proportion of patients alive and disability-free at 3 months, but higher doses of the drug appear to increase the risk of symptomatic intracranial hemorrhage and reduce efficacy. Although the evidence is not conclusive, it suggests that, with modified dosing, ancrod could yield a favorable risk-benefit ratio in stroke by limiting the risk of symptomatic intracranial hemorrhage.
机译：丙烯醛的直接作用是纤维蛋白原化。这导致了几种次生效应，它们将丙烯醛与典型的溶栓剂（如rt-PA）区分开。间接纤维蛋白溶解，纤维蛋白沉积减少和血液粘度降低的联合作用代表了一系列作用，这些作用在各种血栓形成情况下均应是有益的。近年来，用ancrod进行的最彻底的探索是将其急性应用于缺血性中风。两项临床研究（其中一项具有6小时的治疗时间）已表明，在3个月内增加活着和无残疾患者的比例方面具有显着的益处，但是更高剂量的药物似乎会增加出现症状的风险颅内出血并降低疗效。尽管证据尚无定论，但它表明，通过调整剂量，ancrod可以通过限制有症状的颅内出血的风险来提高卒中的风险收益比。

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