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首页> 外文期刊>Journal of Toxicology-Toxin Reviews >PREFACE: SNAKE VENOMS AND HEMOSTASIS
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PREFACE: SNAKE VENOMS AND HEMOSTASIS

机译：前言：蛇毒和吐血

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In this special series of Toxin Reviews I have invited leading authorities who have played important roles in the advancement of their fields of toxinology and hemostasis to contribute chapters to this series. I would like to apologize to all of those investigators who have made equally important contributions to this field, but because of space limitations could not be included in this special series. In preparing these chapters, the authors were asked to present a brief review of the field as well as provide an update on their own research activity. This special series contains thirteen chapters covering many areas of research interest and clinical studies related to the effects of snake venoms on the hemostatic system. In the first Chapter Dr. Neville A. Marsh opens the series with a brief, but very interesting, historical overview of snake venoms that affect hemostasis. As so elegantly pointed out by Marsh: "These toxins are diverse both in form and function: whilst once the source of prolific basic research, snake venom toxins now afford many opportunities for both clinical and laboratory use." The first chapter is followed by four chapters describing the effect of snake venoms on different factors in the coagulation cascade. In Chapter 2, Drs. Gerry A. F. Nicolaes and Jan Rosing describe the activation and inactivation of blood coagulation factor V by snake venom proteinases. In Chapter 3, Drs. Juri Siigur and Ene Siigur discuss the structure and function of Factor X activating proteinases from snake venoms. In Chapter 4, Dr. Manjunatha Kini and Md. Abu Reza discuss structural characteristics and evolution of the venom prothrombin activators and blood coagulation factors from Australian snakes. In Chapter 5, Drs. Helena C. Castro and Carlos Rangel Rodrigues focus on the current status of snake venom defibrinogenating (thrombin-like) enzymes with particular reference to those enzymes whose structures have been studied in detail. In putting together this series, I attempted to include several chapters on the diagnostic use and clinical applications of snake venom proteins and the next two chapters are specifically directed towards this goal.
机译：在这本《毒素评论》特别系列中，我邀请了在其毒素学和止血领域的发展中发挥了重要作用的主要机构为该系列撰写章节。我想对在这一领域做出同样重要贡献的所有调查人员表示歉意，但由于篇幅所限，不能纳入本专题丛书。在准备这些章节时，要求作者简要介绍该领域，并提供他们自己的研究活动的最新信息。这个特别的系列包含十三章，涵盖了与蛇毒对止血系统的影响有关的许多研究领域和临床研究。在第一章中，内维尔·马什（Neville A. Marsh）博士以简短但非常有趣的，历史悠久的影响止血的蛇毒的概述来介绍该系列。正如Marsh优雅指出的那样：“这些毒素的形式和功能各不相同：虽然蛇毒毒素曾经是基础研究的丰硕成果，但现在为临床和实验室使用提供了许多机会。”第一章后面是四章，描述蛇毒对凝血级联反应中不同因素的影响。在第2章中，Dr。 Gerry A. F. Nicolaes和Jan Rosing描述了蛇毒蛋白酶对凝血因子V的激活和灭活。在第3章中，Dr。 Juri Siigur和Ene Siigur讨论了蛇毒中X因子激活蛋白酶的结构和功能。在第4章中，Manjunatha Kini博士和Abu Reza博士讨论了澳大利亚蛇毒液凝血酶原激活剂的结构特征和演变以及凝血因子。在第5章中，Dr。海伦娜·卡斯特罗（Helena C. Castro）和卡洛斯·兰格尔·罗德里格斯（Carlos Rangel Rodrigues）着重研究蛇毒除纤维蛋白原化酶（凝血酶样酶）的现状，特别是对那些已对其结构进行了详细研究的酶。在整理本系列文章时，我尝试包括关于蛇毒蛋白的诊断用途和临床应用的几章，接下来的两章专门针对此目标。

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