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首页> 外文期刊>Journal of Veterinary Research >Changes in blood parameters induced by experimental jaagsiekte sheep retrovirus infection
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Changes in blood parameters induced by experimental jaagsiekte sheep retrovirus infection

机译：实验性Jaagsiekte绵羊逆转录病毒感染引起的血液参数变化

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The aim of the study was to assess the changes of blood parameters in 12 three-week-old Polish Merino sheep subjected to experimental jaagsiekte sheep retrovirus (JSRV) infection. Material and Methods: Haematological (WBC with leukocyte subpopulations: GRA, LYM, MID, and RBC, MCV, MCH, MCHC, HGB, HCT, PLT, and MPV) and biochemical blood parameters (acid/base balance, cation/anion content, and gasometry) were determined in blood samples collected one month after JSRV infection, then at four-week intervals for five consecutive months. Results: A decrease in RBC, HCT, MCV, PLT, MPV, and LYM values in comparison with controls was found in the last month of observation. On the other hand, at the same time, an increase in HGB, MCH, MCHC, WBC, MID, and GRA indices was observed. Moreover, at the end of experiment blood gasometric indices such as pCO(2), HCO3, and tCO(2), and Na and K ion concentrations were higher in the affected lambs than in the healthy animals. The pH values of the challenged animals exhibited less alkaline character than in the case of controls, which was associated with a decrease in O-2% saturation. However, the majority of differences between JSRV inoculated and control groups was not statistically significant. Conclusion: The observed changes in the examined blood parameters can be considered as prodromal symptoms in the preclinical phase of adenocarcinoma development associated with JSRV infection.
机译：这项研究的目的是评估12只三周大的波兰美利奴绵羊的血液参数变化，这些绵羊受到实验性Jaagsiekte绵羊逆转录病毒（JSRV）感染。材料和方法：血液学（白细胞亚群的WBC：GRA，LYM，MID和RBC，MCV，MCH，MCHC，HGB，HCT，PLT和MPV）和生化血液参数（酸/碱平衡，阳离子/阴离子含量，在JSRV感染后1个月收集的血液样本中进行测定（并进行胃压测定），然后每4周间隔连续5个月。结果：在观察的最后一个月，与对照组相比，RBC，HCT，MCV，PLT，MPV和LYM值降低。另一方面，同时观察到HGB，MCH，MCHC，WBC，MID和GRA指数增加。此外，在实验结束时，受影响的羔羊的血液胃压指数（例如pCO（2），HCO3和tCO（2））以及Na和K离子浓度高于健康动物。与对照组相比，受攻击动物的pH值显示出较少的碱性，这与O-2％饱和度降低有关。但是，JSRV接种组和对照组之间的大多数差异在统计学上并不显着。结论：在JSRV感染相关的腺癌发展的临床前阶段，所检查的血液参数的变化可被视为前驱症状。

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