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首页> 外文期刊>Journal of women’s health >Hormone therapy and risk of lung cancer: a meta-analysis.
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Hormone therapy and risk of lung cancer: a meta-analysis.

机译：激素治疗与肺癌风险：一项荟萃分析。

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BACKGROUND: The association between hormone therapy (HT) use and lung cancer risk is inconsistent in epidemiological studies. This meta-analysis was conducted to examine the association between HT and lung cancer risk. METHODS: We searched MEDLINE (PubMed), EMBASE, and the Cochrane Library in April 2008. All articles searched were independently reviewed and selected by two evaluators according to predetermined inclusion and exclusion criteria. RESULTS: We included a total of 11 studies (8 case-control studies and 3 prospective cohort studies), involving a total of 220,599 participants. When all studies were pooled, the odds ratio (OR) of HT use for lung cancer risk was 0.87 (95% confidence interval (CI) 0.74-1.02). In subgroup meta-analyses, there was no association among cohort studies (relative risk (RR) 1.01; 95% CI 0.74-1.38), while there was a significant association between HT use and lung cancer risk among case-control studies (OR 0.81; 95% CI 0.68-0.97) based on a random-effects model. No significant association between HT use and lung cancer risk was observed in most of the subgroup meta-analyses by methodological quality of study, type of HT use, duration of HT use, and histology of lung cancer, while significant protective effects were observed among former and never smokers except for current smokers. However, cumulative meta-analyses based on year of publication showed a distinct trend toward a protective effect of HT use on lung cancer risk in the recent studies. CONCLUSIONS: Overall, the findings of this meta-analysis do not support the hypothesis that there is a link between HT use and lung cancer risk. Our findings should be evaluated in further prospective cohort studies.
机译：背景：在流行病学研究中，激素治疗（HT）的使用与肺癌风险之间的关联是不一致的。进行这项荟萃分析，以检查HT与肺癌风险之间的关系。方法：我们于2008年4月搜索了MEDLINE（PubMed），EMBASE和Cochrane图书馆。所有检索到的文章均由两名评估人员根据预定的纳入和排除标准进行独立审查和选择。结果：我们纳入了总共11项研究（8项病例对照研究和3项前瞻性队列研究），共有220,599名参与者。汇总所有研究后，使用HT治疗肺癌的几率（OR）为0.87（95％置信区间（CI）为0.74-1.02）。在亚组荟萃分析中，队列研究之间没有关联（相对风险（RR）1.01; 95％CI 0.74-1.38），而病例对照研究中HT使用与肺癌风险之间存在显着关联（OR 0.81） ; 95％CI 0.68-0.97）基于随机效应模型。通过研究的方法学质量，HT使用类型，HT使用时间和肺癌组织学，在大多数亚组荟萃分析中，未发现HT使用与肺癌风险之间有显着关联，而在前者中观察到显着的保护作用。除目前吸烟者外，从不吸烟。然而，在最近的研究中，基于发表年份的累积荟萃分析显示了使用HT预防肺癌风险的明显趋势。结论：总体而言，这项荟萃分析的结果不支持以下假设，即使用HT和肺癌风险之间存在联系。我们的发现应在进一步的前瞻性队列研究中进行评估。

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