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首页> 外文期刊>Diabetes/metabolism research and reviews >Insulin resistance in type 1 diabetes.
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Insulin resistance in type 1 diabetes.

机译：1型糖尿病的胰岛素抵抗。

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Insulin resistance plays a larger role in the type 1 diabetes disease process than is commonly recognized. The onset of type 1 diabetes is often heralded by an antecedent illness and/or the onset of puberty, both conditions associated with insulin resistance. In the face of a damaged beta-cell and thus reduced insulin secretion, this change is enough to manifest hyperglycemia. During the first year of clinical disease, considerable evidence suggests that the occurrence of clinical remission or 'honeymoon period' is due to a temporary resolution of the insulin-resistant state present at diagnosis. Intensive diabetes management is associated with both improved insulin sensitivity and beta-cell function. This indicates that the historical data on the changes in insulin secretion post-diagnosis may be inappropriate when designing current studies. The known physiological relationship between beta-cell function and insulin sensitivity complicates interpretation of insulin secretion data obtained as part of prevention or intervention trials. While it is recommended that at least a subset of subjects participating in these trials undergo formal measurements of insulin sensitivity to evaluate effects of therapy on this parameter independent of effects on the beta-cell, the sample size must be sufficient to determine an effect if present. Finally, one could speculate that it is possible that subsets of people with mild manifestations of the type 1 autoimmune disease process could benefit from treatments aimed at improving the insulin-resistant state.
机译：胰岛素抵抗在1型糖尿病的发病过程中起着比通常公认的更大的作用。 1型糖尿病的发作通常是由先前的疾病和/或青春期的发作预示的，这两种情况均与胰岛素抵抗相关。面对受损的β细胞并因此减少胰岛素分泌，这种变化足以表现出高血糖症。在临床疾病的第一年，大量证据表明，临床缓解或“蜜月期”的发生是由于诊断时出现的胰岛素抵抗状态的暂时消退。强化糖尿病治疗与改善的胰岛素敏感性和β细胞功能有关。这表明在设计当前研究时，有关胰岛素分泌改变后诊断的历史数据可能不合适。 β细胞功能与胰岛素敏感性之间的已知生理关系使作为预防或干预试验一部分而获得的胰岛素分泌数据的解释变得复杂。建议至少参加这些试验的受试者的一部分接受胰岛素敏感性的正式测量，以评估该参数对β参数的影响，独立于对β细胞的影响，但样本量必须足以确定其影响（如果存在） 。最后，人们可能会推测，患有1型自身免疫疾病过程的轻度表现的人群可能会受益于旨在改善胰岛素抵抗状态的治疗。

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