Gene therapy for breast cancer

Takahashi S; Hatake K; Sugimoto Y

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Gene therapy for breast cancer

机译：乳腺癌的基因治疗

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Breast cancer is sensitive to chemotherapy and endocrine therapy, but the prognosis of advanced or relapsed breast cancer is unsatisfactory. Gene therapy is promising as another useful therapeutic approach for advanced breast cancer. Strategies of gene therapy for breast cancer in ongoing clinical protocols can be divided into four: (1) suppression of oncogenes or transduction of tumor suppressors; (2) enhancement of immunological response to cancer cells; (3) transduction of suicide genes; and (4) protection of bone marrow using drug resistance genes. We have started a clinical study of gene therapy for breast cancer using multidrug resistance gene (MDR1), in which advanced or relapsed breast cancer patients received high dose chemotherapy and autologous peripheral blood stem cell transplantation (PBSCT) with MDR1-transduced hemopoietic cells, and then were treated with docetaxel. Two patients have been treated so far, and in vivo enrichment of MDR1-transduced cells with docetaxel treatment after PBSCT was seen in both cases. Both patients are in complete remission and have no apparent adverse effect from MDR1 gene transduction.

机译：乳腺癌对化学疗法和内分泌疗法敏感，但是晚期或复发性乳腺癌的预后并不令人满意。基因治疗有望成为晚期乳腺癌的另一种有用的治疗方法。正在进行的临床方案中的乳腺癌基因治疗策略可分为四类：（1）抑制癌基因或转导肿瘤抑制因子; （2）增强对癌细胞的免疫反应; （3）自杀基因的转导; （4）利用耐药基因保护骨髓。我们已经开始使用多药耐药基因（MDR1）对乳腺癌进行基因治疗的临床研究，其中晚期或复发性乳腺癌患者接受了大剂量化疗和MDR1诱导的造血细胞自体外周血干细胞移植（PBSCT），以及然后用多西他赛治疗。到目前为止，已有两名患者接受了治疗，在两种情况下均发现在多药紫杉醇治疗后多西他赛可体内富集MDR1转导的细胞。两名患者均已完全缓解，并且没有MDR1基因转导的明显不良反应。

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《癌と化学療法》 |2003年第4期|共10页
作者
Takahashi S; Hatake K; Sugimoto Y;
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正文语种 jpn
中图分类肿瘤学;
关键词
Breast Neoplasms; Gene Therapy; Genes; MDR; Genetic Vectors; Paclitaxel; 乳腺肿瘤; 基因疗法; 基因; MDR; 遗传载体; 紫杉酚; 逆转录病毒科;

机译：Breast Neoplasms;Gene Therapy;Genes;MDR;Genetic Vectors;Paclitaxel;乳腺肿瘤;基因疗法;基因;MDR;遗传载体;紫杉酚;逆转录病毒科;

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专利

1. Gene therapy for breast cancer. — review of clinical gene therapy trials for breast cancer and mdr1 gene therapy trial in cancer institute hospital [J] . Shunji Takahashi, Yoshinori Ito, Kiyohiko Hatake, Breast Cancer . 2006,第1期

机译：乳腺癌的基因治疗。 —癌症研究所医院的乳腺癌临床基因治疗试验和mdr1基因治疗试验的回顾
2. Dysregulation of the Epigenome in Human Breast Cancer Contributions of Gene-Specific DNA Hypermethylation to Breast Cancer Pathobiology and Targeting the Breast Cancer Methylome for Improved Therapy [J] . Sandhu Rupninder, Roll J. Devon, Rivenbark Ashley G., American Journal of Pathology: Official Publication of the American Association of Pathologists . 2015,第2期

机译：对人乳腺癌的外延蛋白酶的表现术失调对乳腺癌病原体的特异性DNA高甲基化的贡献，靶向乳腺癌甲瘤改善治疗
3. Gene expression profiling of breast cancers between high and low Ki-67 after short-term preoperative hormone therapy among hormone receptor-positive / human epidermal growth factor receptor 2-negative breast cancers with high Ki-67 [J] . Intelligence: A Multidisciplinary Journal . 2020,第期

机译：短期术前激素治疗乳腺癌患者乳腺癌在激素受体阳性/人体表皮生长因子受体2阴性乳腺癌中的短期术前激素治疗后乳腺癌的基因表达分析
4. RNA interference mediated knockdown of target genes in clinical research and therapy of breast cancer [C] . Lin Hong, Tang Xiao-Jun, Zhu Jin, International Symposium on Medical and Pharmaceutical Biotechnology(医药生物技术国际研讨会) . 2009

机译：RNA干扰介导的靶基因敲除在乳腺癌临床研究和治疗中的作用
5. Boron Neutron Capture Therapy for HER2+ breast cancers: A feasibility study evaluating BNCT for potential role in breast conservation therapies. [D] . Jenkins, Peter Anthony. 2012

机译：HER2 +乳腺癌的硼中子捕获疗法：评估BNCT在乳腺癌保护疗法中潜在作用的可行性研究。
6. Comparing syngeneic and autochthonous models of breast cancer to identify tumor immune components that correlate with response to immunotherapy in breast cancer [O] . Jessica Castrillon Lal, Madeline G. Townsend, Anita K. Mehta, 2021

机译：与乳腺癌同工和自身加重模型进行比较鉴定与乳腺癌免疫疗法反应相关的肿瘤免疫组分
7. Chemotherapy is one of the therapies for cancer patients that cause some side effects, one of them is nausea and vomiting. Nausea and vomiting are still felt by patients even though they take antiemetics. Nausea dan vomiting can cause fluid and electrolyte imbalance. The aim of this study was to analysis the effect of combination acupressure wristband and antiemetic among chemotherapy induced nausea vomiting (CINV) on breast cancer patients. This research used quasi experimental research method, with a pre-post test with the control group. The sampling techniques was consecutive sampling with 25 respondents both in intervention group and control group. In the intervention group had received an acupressure wristband. CINV measured on the second day until fourth day after chemotherapy. Nausea and vomiting score were measured twice a day by a telemonitoring methode by Rhodes Index Nausea, Vomiting and Retching (INVR) questionaire. Data were analyzed by paired t-test, independent t-test, Wilcoxon test and Mann Whitney. The result of this study showed that acupressure wristband significantly reduce the chemotherapy induced nausea and vomit (p value = 0.000). The use of acupressure wristband combined with antiemetic therapy can significantly decrease chemotherapy induced nausea and vomiting in breast cancer patients. Acupressure wristband recommended for consideration nursing intervention in treating breast cancer patients who experience nausea and vomiting. [O] . Endah Fatma 2018

机译：化疗是癌症患者的疗法之一，导致一些副作用，其中一个是恶心和呕吐。患者仍然感受到恶心和呕吐，即使他们服用助性学。恶心丹呕吐会导致液体和电解质不平衡。本研究的目的是分析组合组合腕带和抑制在乳腺癌患者中的诱导恶心呕吐（CINV）的影响。本研究使用了准实验研究方法，用对照组进行了预先测试。采样技术是在干预组和对照组中进行25名受访者的连续抽样。在干预组中，收到了一名腕带。 Cinv在化疗后第四天测量。通过罗得岛指数恶心，呕吐和转换（INVR）问卷，每天测量恶心和呕吐分数。通过配对的T检验，独立的T检验，Wilcoxon测试和Mann Whitney分析数据。该研究的结果表明，Acuruce腕带显着降低化疗诱导的恶心和呕吐物（P值= 0.000）。使用Acu压抑腕带与止吐疗法相结合，可以显着降低乳腺癌患者诱导的恶心和呕吐。 Acu压痕腕带推荐用于治疗体验恶心和呕吐的乳腺癌患者的护理干预。
8. DNA Base Excision Repair (BER) and Cancer Gene Therapy: Use of the Human N-mythlpurien DNA Glycosylase (MPG) to Sensitize Breast Cancer Cells to Low Dose Chemotherapy [R] . Harvey, T. , Kelly, M. R. 2003

机译：DNa碱基切除修复（BER）和癌症基因治疗：使用人类N-mythlpurien DNa糖基化酶（mpG）使乳腺癌细胞对低剂量化疗敏感

Gene therapy for breast cancer

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