SELECTIVITY AND UPTAKE OF LITHIUM

ANH NGUYEN; D. SCOTT BOHLE

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SELECTIVITY AND UPTAKE OF LITHIUM

机译：锂的选择性和吸收

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Lithium salts arc widely utilized as psychopharmacological agents for the therapy of bipolar disorders and related illnesses. Although it is readily bio-available and has just a single biologically relevant oxidation state, its biological activity remains poorly understood. This comment will examine several key issues in this area: I) Given the chemical properties of lithium, how do ion transport and metal-dependent enzymes mediate the selectivity of lithium and other alkali ions? 2) Is it possible to predict which magnesium-dependent enzymes can be inhibited by lithium? Answers to these questions are now accessible because of the recent structural determinations of ion channels and of magnesium-dependent, lithium-sensitive inositol polyphosphate 1-phosphatase. This comment will attempt to synthesize the dispersed coordination chemistry data for lithium which can help us evaluate these potential targets for lithium therapy

机译：锂盐被广泛用作治疗躁郁症和相关疾病的心理药物。尽管它易于生物利用并且只有一个生物学相关的氧化态，但对其生物学活性仍然知之甚少。该评论将研究该领域的几个关键问题：I）考虑到锂的化学性质，离子迁移和金属依赖性酶如何介导锂和其他碱金属离子的选择性？ 2）是否可以预测锂可以抑制哪些镁依赖性酶？由于离子通道和镁依赖性，对锂敏感的肌醇多磷酸1-磷酸酶的结构最近确定，现在可以找到这些问题的答案。该评论将尝试合成锂的分散配位化学数据，这可以帮助我们评估锂治疗的这些潜在目标

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《Comments on Inorganic Chemistry: A Journal of Critical Discussion of the Current Literature》 |2004年第6期|共18页
作者
ANH NGUYEN; D. SCOTT BOHLE;
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正文语种 eng
中图分类有机化学;
关键词
lithium; magnesium; ion channels; selective inhibitor;

机译：锂;镁;离子通道;选择性抑制剂;

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SELECTIVITY AND UPTAKE OF LITHIUM

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