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Clinical study of 28 children with bacterial meningitis

机译：小儿细菌性脑膜炎28例临床研究

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A retrospective study was conducted on 28 patients with bacterial meningitis who were admitted to our department between April 1988 and March 2002. The most commonly detected pathogen was group B Streptococcus in those under 1 month of age and Haemophilus influenzae (72.2%) among those over 1 month. The most commonly administered antibiotic combination (67.9%) at the initial treatment was that of cefotaxime (CTX) and ampicillin (ABPC). We encountered one case that was resistant to both CTX and ABPC. Through this experience, it became apparent that for the initial treatment of bacterial meningitis in infants, it is necessary to apply a combination of two antibiotics, instead of a single agent, and new antibiotics should be considered for such combinations rather than persisting on conventional CTX and ABPC. The aforementioned 28 patients were divided into 2 groups--7 patients (25.0%) with sequelae and 21 (75.0%) without--and various factors noted during the diagnosis were evaluated retrospectively. It was found that the number of days leading to admission at the hospital and the development of convulsions were unrelated to the prognosis. Those who succumbed or suffered sequelae were all infants under 1 year of age. All cases were caused by genus Haemophilus.
机译：回顾性研究了1988年4月至2002年3月间入院的28例细菌性脑膜炎患者。最常见的病原体是1个月以下的B型链球菌和7％以上的流感嗜血杆菌（72.2％）。 1个月。初始治疗中最常用的抗生素组合（67.9％）是头孢噻肟（CTX）和氨苄西林（ABPC）的组合。我们遇到了一例同时抗CTX和ABPC的病例。通过这种经验，很明显，对于婴儿的细菌性脑膜炎的初始治疗，有必要应用两种抗生素的组合，而不是单一药物，并且对于这种组合，应考虑使用新的抗生素，而不是坚持使用常规的CTX和ABPC。将上述28例患者分为两组，分别是-7例（25.0％）后遗症和21例（75.0％）无后遗症，并对诊断期间发现的各种因素进行回顾性评估。已发现导致入院的天数和惊厥的发展与预后无关。屈服或遭受后遗症的人均为1岁以下的婴儿。所有病例均由嗜血杆菌属引起。

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