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首页> 外文期刊>Comparative biochemistry and physiology, Part C. Pharmacology, toxicology and endocrinology: An international journal >Growth hormone inhibits growth hormone secretion from the rainbow trout pituitary in vitro
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Growth hormone inhibits growth hormone secretion from the rainbow trout pituitary in vitro

机译：生长激素在体外抑制虹鳟垂体的生长激素分泌

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Growth hormone (GH) secretion in salmonids and other fish is under the control of a number of hypothalamic factors, but negative feed-back regulation by circulating hormones can also be of importance for the regulation of GH secretion. Mammalian studies show that GH has a negative feed-back effect on its own secretion. In order to elucidate if GH levels present a direct ultra-short negative feedback loop at the pituitary level GH secretion was studied in intact pituitaries from 50 g fish in an in vitro perifusion system. Following an initial equilibrium period pituitaries were exposed to five increasing concentrations (1-1000 ng ml(-1)) of ovine CH (oGH) in 20-min steps, before being returned to a GH-free perifusion. Ovine GH caused a significant dose-dependant inhibition of GH secretion and it is concluded that GH can exert a direct negative feedback control on GH secretion at the pituitary level. (C) 2000 Elsevier Science Inc. All rights reserved. [References: 27]
机译：鲑鱼和其他鱼类中生长激素（GH）的分泌受许多下丘脑因子的控制，但是循环激素的负反馈调节对GH分泌的调节也很重要。哺乳动物的研究表明，GH对自身分泌具有负面的反馈作用。为了阐明GH水平是否在垂体水平存在直接的超短负反馈回路，在体外灌注系统中研究了来自50 g鱼的完整垂体中的GH分泌。在最初的平衡期后，垂体在20分钟的时间内暴露于五种递增浓度（1-1000 ng ml（-1））的绵羊CH（oGH）中，然后恢复为无GH的灌注。绵羊生长激素对生长激素的分泌具有明显的剂量依赖性抑制作用，因此得出结论，生长激素可以在垂体水平上对生长激素的分泌产生直接的负反馈控制。 （C）2000 Elsevier Science Inc.保留所有权利。 [参考：27]

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