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Monkey B virus (Cercopithecine herpesvirus 1)

机译:猴B病毒(Cercopithecine疱疹病毒1)

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摘要

Macaques are a particularly valuable nonhuman primate model for a wide variety of biomedical research endeavors. B virus (Cercopithecine herpesvirus 1; BV) is an alpha-herpesvirus that naturally infects conventional populations of macaques. Serious disease due to BV is rare in macaques, but when transmitted to humans, BV has a propensity to invade the central nervous system and has a fatality rate greater than 70% if not treated promptly. The severe consequences of human BV infections led to the inclusion of BV in the original NIH list of target viruses for elimination by development of specific pathogen-free rhesus colonies. In macaques and especially in humans, diagnosis of BV infection is not straightforward. Furthermore, development and maintenance of true BV specific pathogen-free macaque colonies has proven difficult. In this overview we review the natural history of BV in macaques, summarize what is known about the virus at the molecular level, and relate this information to problems associated with diagnosis of BV infections and development of BV-free macaque colonies.
机译:猕猴是用于各种生物医学研究工作的特别有价值的非人类灵长类动物模型。 B病毒(Cercopithecine疱疹病毒1; BV)是自然感染常规猕猴种群的α疱疹病毒。由于BV引起的严重疾病在猕猴中很少见,但是当BV传播给人类时,BV倾向于侵入中枢神经系统,如果不及时治疗,其病死率会超过70%。人类BV感染的严重后果导致BV被包括在最初的NIH目标病毒列表中,以通过发展无病原体的恒河猴菌落来消除。在猕猴中,尤其是在人类中,BV感染的诊断并不简单。此外,已经证明开发和维持真正的无BV特异性无病原体的猕猴菌落很困难。在本概述中,我们回顾了猕猴中BV的自然历史,总结了在分子水平上有关该病毒的已知知识,并将此信息与BV感染的诊断和无BV猕猴菌落发展相关的问题相关联。

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