...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental pharmacology & physiology >Hypotensive and lipid regulatory actions of 4-hydroxyderricin, a chalcone from Angelica keiskei, in stroke-prone spontaneously hypertensive rats.
【24h】

Hypotensive and lipid regulatory actions of 4-hydroxyderricin, a chalcone from Angelica keiskei, in stroke-prone spontaneously hypertensive rats.

机译：当归自发性高血压大鼠中一种来自当归的查尔酮的4-羟基derricin的降压和脂质调节作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

SUMMARY 1. Previously, we found that Angelica keiskei extract (ethyl acetate extract from the yellow liquid of stems) elevated serum high-density lipoprotein (HDL) levels and reduced liver triglyceride content in stroke-prone spontaneously hypertensive rats (SHRSP). To identify the active substance in A. keiskei extract, we examined the effect of 4-hydroxyderricin, a characteristic chalcone isolated from the yellow liquid of stems, on blood pressure and lipid metabolism in SHRSP. 2. Six-week-old male SHRSP were fed diets containing 0.07% 4-hydroxyderricin for 7 weeks with free access to the diet and water. Elevation of systolic blood pressure was significantly suppressed after 7 weeks treatment. Serum very low-density lipoprotein (VLDL) levels were significantly reduced, without any effect on HDL levels, and were associated with a significant decrease in the serum concentration of free fatty acids. 3. In the liver, significant decreases in relative liver weight and triglyceride content were found aftertreatment with 4-hydroxyderricin for 7 weeks. 4. An investigation of hepatic mRNA expression of proteins involved in lipid metabolism indicated that a significant decrease in microsomal triglyceride transferprotein may be responsible for the decrease in serum VLDL levels and that significant decreases in adipocyte determination and differentiation factor 1 and fatty acid synthase may be responsible for the decrease in hepatic triglyceride content. 5. In conclusion, dietary 4-hydroxyderricin produces suppression of the elevation of systolic blood pressure, reduction of serum VLDL levels and a decrease in hepatic triglyceride content in SHRSP.
机译：概述1.以前，我们发现当归易发性高血压大鼠（SHRSP）的当归提取物（茎黄色液体中的乙酸乙酯提取物）可提高血清高密度脂蛋白（HDL）水平，并降低肝甘油三酸酯含量。为了鉴定A. keiskei提取物中的活性物质，我们检查了从茎黄色液体中分离出的特征查尔酮4-羟色菊素对SHRSP中血压和脂质代谢的影响。 2.给六周大的雄性SHRSP饲喂含0.07％4-羟基derricin的日粮，持续7周，并自由饮食和饮水。治疗7周后，收缩压的升高被显着抑制。血清极低密度脂蛋白（VLDL）水平显着降低，而对HDL水平无任何影响，并且与血清游离脂肪酸浓度显着降低有关。 3.在肝脏中，用4-羟基金丝桃素治疗7周后，相对肝脏重量和甘油三酯含量显着下降。 4.对参与脂质代谢的蛋白质的肝mRNA表达的研究表明，微粒体甘油三酸酯转移蛋白的显着降低可能是血清VLDL水平降低的原因，而脂肪细胞测定和分化因子1和脂肪酸合酶的显着降低可能是造成肝甘油三酯含量降低的原因。 5.总而言之，饮食中的4-羟基derricin可抑制收缩压的升高，血清VLDL水平的降低以及SHRSP中肝甘油三酯含量的降低。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号