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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Inhibitory effect of 1,8-cineole on guinea-pig airway challenged with ovalbumin involves a preferential action on electromechanical coupling.
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Inhibitory effect of 1,8-cineole on guinea-pig airway challenged with ovalbumin involves a preferential action on electromechanical coupling.

机译：1,8-桉树脑对用卵清蛋白攻击的豚鼠气道的抑制作用涉及对机电耦合的优先作用。

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1. 1,8-Cineole is a terpenoid constituent of essential oils with anti-inflammatory properties. It reduces the neural excitability, functions as an antinociceptive agent and has myorelaxant actions in guinea-pig airways. The aim of the present study was to investigate the mechanism underlying the myorelaxant effects of 1,8-cineole in guinea-pig isolated trachea from either naive guinea-pigs or ovalbumin (OVA)-sensitized animals subjected to antigenic challenge. 2. Isometric recordings were made of the tone of isolated tracheal rings. Rings with an intact epithelium relaxed beyond basal tone in the presence of 1,8-cineole (6.5 x 10(-6) to 2 x 10(-2) mol/L) in a concentration-dependent manner (P < 0.001, anova) with a pD(2) value of 2.23 (95% confidence interval 2.10-2.37). Removal of the epithelium or pretreatment of intact tissue for 15 min with 50 micromol/L N(G)-nitro-l-arginine methyl ester, 5 mmol/L tetraethylammonium, 0.5 micromol/L tetrodotoxin or 5 micromol/L propranolol did not alter the potency (pD(2)) or the maximal myorelaxant effect (E(max)) of 1,8-cineole. 3. 1,8-Cineole also significantly decreased the Schultz-Dale contraction induced by OVA, mainly in preparations from OVA-sensitized animals submitted to antigen challenge. 1,8-Cineole decreased tracheal hyperresponsiveness to KCl and carbachol caused by antigen challenge and almost abolished the concentration-response curves to KCl, whereas it had little effect on the concentration-response curves to carbachol. Under Ca(2+)-free conditions and in the presence of 10(-4) mol/L acetylcholine, neither 1,8-cineole (6.5 x 10(-3) mol/L) nor verapamil (1 x 10(-5) mol/L) affected Ca(2+)-induced contractions, but they almost abolished Ba(2+)-induced contractions. 4. In conclusion, the findings of the present study show that 1,8-cineole is a tracheal myorelaxant that acts preferentially on contractile responses elicited electromechanically.
机译：1. 1,8-Cineole是具有抗炎特性的精油中的萜类成分。它会降低神经兴奋性，起镇痛作用，并在豚鼠气道中具有肌松作用。本研究的目的是研究从天然天竺鼠或卵清蛋白（OVA）致敏的动物接受抗原攻击后，豚鼠分离的气管中1,8-桉树脑的肌松弛缓作用的潜在机制。 2.等距记录是孤立的气管环的音调。在存在1,8-桉树脑（6.5 x 10（-6）到2 x 10（-2）mol / L）的情况下，具有完整上皮的环以基调松弛，且呈浓度依赖性（P <0.001，方差分析） ）的pD（2）值为2.23（95％置信区间2.10-2.37）。用50 micromol / LN（G）-硝基-1-精氨酸甲酯，5 mmol / L四乙基铵，0.5 micromol / L河豚毒素或5 micromol / L普萘洛尔去除上皮或对完整组织进行预处理15分钟不会改变效力（pD（2））或1,8-桉树脑的最大肌松药效果（E（max））。 3. 1,8-Cineole也显着降低了OVA引起的舒尔茨-戴尔收缩，主要是在OVA致敏动物接受抗原攻击后制成的。 1,8-Cineole降低了抗原挑战引起的气管对KCl和卡巴胆碱的高反应性，并几乎消除了对KCl的浓度-反应曲线，而对卡巴胆碱的浓度-反应曲线影响很小。在无Ca（2+）的条件下，在10（-4）mol / L乙酰胆碱的存在下，1,8-桉树脑（6.5 x 10（-3）mol / L）或维拉帕米（1 x 10（- 5）mol / L）影响Ca（2+）引起的收缩，但它们几乎废除了Ba（2+）引起的收缩。 4.总而言之，本研究的结果表明，1，8-桉树脑是一种气管肌肉松弛剂，其优先作用于机电引起的收缩反应。

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