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Rheological Study of Genipin Cross-Linked Chitosan Hydrogels

机译：Genipin交联壳聚糖水凝胶的流变学研究

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摘要

This paper reports the rheological behavior of chitosan solutions that have been cross-linked with different amounts of genipin, at body temperature and physiological pH. The effect of the cross-linker loading on the rheological properties of hydrogels has been evaluated. The oscillatory time sweep method was used to monitor the dynamic viscoelastic parameters during in situ (i.e., in the rheometer) gelation experiments, enabling the determination of the gelation time. The stress and frequency sweeps were employed to measure G' of the cured hydrogels. It was found that the solutions of chitosan cross-linked with genipin, under physiological conditions, could form relatively strong elastic gels when compared to those of pure chitosan. Moreover, the gelation time obtained from the crossover of G" and G' was in excellent agreement with the value obtained from the Winter-Chambon criterion. A significant reduction on this parameter was achieved even at low genipin concentrations. This behavior suggests that these formulations are able to be produced in situ and thus constitute promising matrices for cells and bioactive molecule encapsulations.
机译：本文报道了在室温和生理pH下，已与不同量的京尼平交联的壳聚糖溶液的流变行为。已经评估了交联剂负载对水凝胶流变性质的影响。振荡时间扫描法用于在原位（即在流变仪中）胶凝实验期间监测动态粘弹性参数，从而能够确定胶凝时间。应力和频率扫描被用来测量固化的水凝胶的G'。已经发现，与纯壳聚糖相比，在生理条件下与genipin交联的壳聚糖溶液可以形成相对较强的弹性凝胶。此外，从G“和G'交叉获得的胶凝时间与从Winter-Chambon准则获得的值非常吻合。即使在低京尼平浓度下，该参数也显着降低。这种行为表明这些制剂能够原位产生，因此构成用于细胞和生物活性分子包封的有前途的基质。

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