Regulatory T Cells in Allogeneic Stem Cell Transplantation

Maria Michael; Avichai Shimoni; Arnon Nagler

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Regulatory T Cells in Allogeneic Stem Cell Transplantation

机译：同种异体干细胞移植中的调节性T细胞

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Growing evidence suggests that cellular adoptive immunotherapy is becoming an attractive though challenging approach in regulating tumor immunity and alloresponses in clinical transplantation. Naturally arising CD4+CD25+Foxp3+ regulatory T cells (Treg) have emerged as a key component in this regard. Over the last decade, a large body of evidence from predinical models has demonstrated their crucial role in auto- and tumor immunity and has opened the door to their "first-in-man" clinical application. Initial studies in clinical allogeneic stem cell transplantation are very encouraging and may pave the way for other applications. Further improvements in Treg ex vivo or in vivo expansion technologies will simplify their global clinical application. In this review, we discuss the current knowledge of Treg biology and their potential for cell-based immunotherapy in allogeneic stem cell transplantation.

机译：越来越多的证据表明，在临床移植中，细胞过继免疫疗法正在成为一种有吸引力但具有挑战性的方法，用于调节肿瘤免疫力和过敏反应。自然产生的CD4 + CD25 + Foxp3 +调节性T细胞（Treg）已成为这方面的关键组成部分。在过去的十年中，来自常规模型的大量证据证明了它们在自身和肿瘤免疫中的关键作用，并为他们的“第一人称”临床应用打开了大门。临床上的同种异体干细胞移植的初步研究非常令人鼓舞，并可能为其他应用铺平道路。 Treg离体或体内扩增技术的进一步改进将简化其全球临床应用。在这篇综述中，我们讨论了Treg生物学的最新知识及其在异基因干细胞移植中基于细胞的免疫治疗的潜力。

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《Clinical & developmental immunology.》 |2013年第1期|共9页
作者
Maria Michael; Avichai Shimoni; Arnon Nagler;
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正文语种 eng
中图分类免疫性疾病;
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1. Interleukin-10 Gene-Modified Dendritic Cell-Induced Type 1 Regulatory T Cells Induce Transplant-Tolerance and Impede Graft Versus Host Disease After Allogeneic Stem Cell Transplantation [J] . Jiangbo Wan, Fang Huang, Siguo Hao, Cellular Physiology and Biochemistry . 2017,第1期

机译：白细胞介素10基因修饰的树突状细胞诱导的1型调节性T细胞诱导同种异体干细胞移植后的移植耐受性和移植物抗宿主病。
2. CTLA-4 blockade following relapse of malignancy after allogeneic stem cell transplantation is associated with T cell activation but not with increased levels of T regulatory cells. [J] . Zhou J, Bashey A, Zhong R, Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation . 2011,第5期

机译：同种异体干细胞移植后恶性肿瘤复发后的CTLA-4阻断与T细胞活化有关，但与T调节细胞水平升高无关。
3. Peripheral blood regulatory T cells and occurrence of Cytomegalovirus DNAemia after unmanipulated haploidentical allogeneic hematopoietic stem cell transplantation with posttransplant cyclophosphamide [J] . Bone marrow transplantation . 2020,第7期

机译：外周血调节性T细胞和患有直植物后环磷酰胺的非法寄生血管生成的造血干细胞移植后患有细胞瘤性腺病毒DNAEMIA的发生
4. SmartTransplantation - Allogeneic Stem Cell Transplantation as a Model for a Medical Expert System [C] . Gerrit Meixner, Nancy Thiels, Ulrike Klein Symposium of the Workshop on Human-Computer Interaction and Usability Engineering of the Austrian Computer Society(USAB 2007); 20071122; Graz(AT) . 2007

机译：SmartTransplantation-同种异体干细胞移植作为医学专家系统的模型
5. Donor selection for patients undergoing allogeneic hematopoietic stem cell transplantation: Assessment of the priorities of Canadian hematopoietic stem cell transplant physicians. [D] . Tay, Jason. 2009

机译：接受同种异体造血干细胞移植的患者的供体选择：加拿大造血干细胞移植医生的优先事项评估。
6. CTLA-4 Blockade following Relapse of Malignancy after Allogeneic Stem Cell Transplantation is Associated with T cell Activation but not Increased Levels of T Regulatory Cells [O] . Jiehua Zhou, Asad Bashey, Ruikun Zhong, -1

机译：CTLa-4阻断同种异体干细胞移植后以下恶性肿瘤复发是相关与T细胞激活但不增加调节性T细胞的水平
7. Interleukin-10 Gene-Modified Dendritic Cell-Induced Type 1 Regulatory T Cells Induce Transplant-Tolerance and Impede Graft Versus Host Disease After Allogeneic Stem Cell Transplantation [O] . Jiangbo Wan, Fang Huang, Siguo Hao, 2017

机译：白细胞介素-10基因修饰的树突状细胞诱导的1型调节性T细胞诱导异基因干细胞移植后的移植耐受性和阻生移植物与宿主疾病

Regulatory T Cells in Allogeneic Stem Cell Transplantation

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