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Nitric oxide and cardiac failure

机译：一氧化氮与心力衰竭

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AIM: To study the synthesis of nitric oxide II (NO) in patients with acute myocardial infarction (AMI) and patients with postinfarction cardiosclerosis (PICS) with chronic cardiac failure (CCF). MATERIAL AND METHODS: The study included 125 patients: 35 patients with Q-wave AMI and 90 PICS patients. AMI patients were examined clinically, device and laboratory tests were made to measure NO metabolites in the urine, plasma, culture medium of peripheral blood mononuclear cells on MI day 1 and 21, iNOS was estimated in mononuclear cells of peripheral blood on MI days 1, 2, 7, 14 and 21. PICS patients examination incorporated assays for NO metabolites in 24-h urine and plasma, in blood lymphocytes on MI day 1, 14 and 28.2 days before NO tests, all nutritional nitrates and nitrites were excluded from the diet. Control group consisted of 15 nonsmokers aged 33 to 53 years (mean age 43.7 +/- 9.3 years). The level of NO metabolites in the urine was 49.7 mcM, in plasma--19.7 mcM, in lymphocyte culture--28.8 mcM. RESULTS: By urinary nitritesitrates all the MI examinees were divided into three subgroups: with low, moderate and high levels content of nitrites and nitrates (subgroups 1, 2 and 3, respectively). The correlation analysis has established significant correlations between NO metabolites in urine and plasma in the first MI hours and the data on the clinical status, device characteristics of myocardial lesion extention and prognosis of the disease. The most severe MI course and PICS was seen in subgroup 1, of moderate severity--in subgroup 3, a favourable course--in subgroup 2. CONCLUSION: Assay for nitrites and nitrates in the urine and plasma is necessary for selection of pathogenetically validated prescription of nitrates to AMI and PICS patients.
机译：目的：研究急性心肌梗死（AMI）和慢性心力衰竭（CCF）的梗死后心硬化（PICS）患者一氧化氮II（NO）的合成。材料与方法：该研究包括125例患者：35例Q波AMI患者和90例PICS患者。在AMI第1天和第21天对AMI患者进行临床检查，设备和实验室测试以测量尿，血浆，外周血单个核细胞培养基中的NO代谢物，在MI第1天估计外周血单个核细胞中的iNOS。 2、7、14和21。PICS患者检查在NO测试前第1、14和28.2天的MI第24天尿液和血浆中的血淋巴细胞中NO代谢物的测定方法中，所有营养硝酸盐和亚硝酸盐均排除在饮食之外。对照组由15位年龄在33至53岁（平均年龄43.7 +/- 9.3岁）的不吸烟者组成。尿液中NO代谢物的水平为49.7 mcM，血浆为-19.7 mcM，淋巴细胞培养物为-28.8 mcM。结果：通过尿中的亚硝酸盐/硝酸盐，所有MI考生都分为三个亚组：亚硝酸盐和硝酸盐含量低，中和高水平（分别为第1、2和3个亚组）。相关性分析已经建立了在最初的MI小时中尿液和血浆中NO代谢物与临床状况，心肌病变范围的器械特征和疾病预后之间的显着相关性。在亚组1中观察到最严重的MI病程和PICS，在亚组3中观察到中度病情-在亚组3中为有利病程。 AMI和PICS患者的硝酸盐处方。

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